101993-20-8

Basic information

• Product Name: Benzofuran, 2-(4-fluorophenyl)-5-nitro-
• CAS NO: 101993-20-8
• Molecular Formula: C14H8FNO3
• Molecular Weight: 257.221
• Mol File: 101993-20-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzofuran, 2-(4-fluorophenyl)-5-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzofuran, 2-(4-fluorophenyl)-5-nitro-(101993-20-8)
• EPA Substance Registry System: Benzofuran, 2-(4-fluorophenyl)-5-nitro-(101993-20-8)

Safety Data

• Hazardous Substances Data: 101993-20-8(Hazardous Substances Data)

Upstream product

• 100-02-7 4-nitro-phenol 
• 405-99-2 para-fluorostyrene 
• 1447448-24-9 C₁₄H₈FNO₃ 
• 95895-33-3 1-(bromoethynyl)-4-fluorobenzene 

Relevant articles and documents

Recyclable [bmIm]OH promoted one-pot heterocyclization: Synthesis of substituted benzofurans

A single step access to polysubstituted benzo[b]furans has been achieved under simple and eco-compatible conditions. The heterocyclization proceeded efficiently. [bmIm]OH played a triple role as a solvent, base as well as catalyst.

Sequential and one-pot reactions of phenols with bromoalkynes for the synthesis of (Z)-2-bromovinyl phenyl ethers and benzo[ b ]furans

Benzo[b]furans were prepared in one pot based on the addition/palladium- catalyzed C-H bond functionalization of phenols with bromoalkynes. The addition reactions of phenols to bromoalkynes generated (Z)-2-bromovinyl phenyl ethers in high yields with excellent regio- and stereoselectivity. The obtained (Z)-2-bromovinyl phenyl ethers subsequently proceeded by intramolecular cyclization to afford 2-substituted benzo[b]furans in good yields through palladium-catalyzed direct C-H bond functionalizations. It is important to note that the transformation of phenols with bromoalkynes into benzo[b]furans could be carried out in one pot with a simple and efficient tandem procedure.