10201-73-7 Usage
Description
2-Amino-4-methoxypyridine is an organic compound characterized by its pale yellow solid appearance. It is known for its highly selective nature as an inhibitor of inducible nitric oxide synthase (iNOS), which plays a significant role in various physiological and pathological processes.
Uses
Used in Pharmaceutical Industry:
2-Amino-4-methoxypyridine is used as a pharmaceutical agent for its ability to selectively inhibit iNOS. This property makes it a potential candidate for the development of drugs targeting conditions where iNOS overexpression or dysregulation is implicated, such as inflammatory diseases, autoimmune disorders, and certain types of cancer.
Used in Research Applications:
In the field of scientific research, 2-Amino-4-methoxypyridine serves as a valuable tool for studying the role of nitric oxide (NO) in various biological processes. As a selective iNOS inhibitor, it can help researchers understand the specific contributions of iNOS-derived NO to cellular signaling, immune responses, and other physiological functions.
Used in Drug Development:
2-Amino-4-methoxypyridine is utilized in the development of novel therapeutics that aim to modulate the activity of iNOS. By inhibiting this enzyme, these drugs may offer potential benefits in treating conditions associated with excessive NO production, such as chronic inflammation, neurodegenerative diseases, and cardiovascular disorders.
Overall, 2-Amino-4-methoxypyridine's unique chemical properties and its role as a selective iNOS inhibitor make it a versatile compound with applications in the pharmaceutical industry, research, and drug development.
Synthesis Reference(s)
The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y
Check Digit Verification of cas no
The CAS Registry Mumber 10201-73-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,2,0 and 1 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 10201-73:
(7*1)+(6*0)+(5*2)+(4*0)+(3*1)+(2*7)+(1*3)=37
37 % 10 = 7
So 10201-73-7 is a valid CAS Registry Number.
InChI:InChI=1/C6H8N2O/c1-9-5-2-3-8-6(7)4-5/h2-4H,1H3,(H2,7,8)
10201-73-7Relevant articles and documents
Improved procedures for preparation of 4-hydroxy- and 2-amemo-4-methoxy-2-aminopyridines
Sundberg, Richard J.,Jiang, Songchun
, p. 117 - 122 (1997)
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A convenient synthetic route to substituted pyrrolo[2,3-b]pyridines via a novel ethylene-bridged compound
Wilding, Birgit,Vidovic, Carina,Klempier, Norbert
, p. 6606 - 6609 (2015)
A convenient synthetic route to 4-substituted pyrrolo[2,3-b]pyridines is presented. The novel ethylene bridged compound 1,2-bis(4-azidopyrrolo[2,3-b]pyridinyl)ethene was prepared and further derivatized. The novel synthesis was applied in the preparation of 3-cyano-4-hydroxypyrrolo[2,3-b]pyridine.
BCR-ABL TYROSINE-KINASE LIGANDS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME
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Paragraph 00592; 00603; 00604, (2015/07/23)
Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. invivo) to form a multimer (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding sites on a Bcr-Abl tyrosine kinase.
Ligandless copper-catalyzed coupling of heteroaryl bromides with gaseous ammonia
Fantasia, Serena,Windisch, Johannes,Scalone, Michelangelo
supporting information, p. 627 - 631 (2013/04/11)
A range of different N- and S-containing heterocyclic bromides can be efficiently coupled with gaseous ammonia in the presence of copper(II) acetylacetonate [Cu(acac)2] as catalyst and in the absence of additional ligands. Unstable aminothiophenes and aminobenzothiophenes can be further reacted in situ to afford functionalized derivatives. Copyright
