10205-62-6

Basic information

• Product Name: 2-(4'-(DIMETHYLAMINO)PHENYL)-6-METHYL-BENZOTHIAZOLE
• Synonyms: n,n-dimethyl-4-(6-methyl-2-benzothiazolyl)-benzenamin;2-(4'-(DIMETHYLAMINO)PHENYL)-6-METHYL-BENZOTHIAZOLE;BTA-2;N,N-dimethyl-4-(6-methylbenzothiazol-2-yl)aniline;N,N-Dimethyl-4-(6-methylbenzothiazol-2-yl)benzenamine;N,N-Dimethyl-4-(6-methylbenzothiazole-2-yl)aniline;N,N-dimethyl-4-(6-methyl-2-benzothiazolyl)-benzenamine;Aniline, N,N-dimethyl-4-(6-methyl-2-benzothiazolyl)-
• CAS NO: 10205-62-6
• Molecular Formula: C₁₆H₁₆N₂S
• Molecular Weight: 268.38
• EINECS: 233-506-7
• Mol File: 10205-62-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 204-206 °C(lit.)
• Boiling Point: 428.8°Cat760mmHg
• Flash Point: 213.1°C
• Appearance: /
• Density: 1.188g/cm³
• Vapor Pressure: 1.48E-07mmHg at 25°C
• Refractive Index: 1.669
• CAS DataBase Reference: 2-(4'-(DIMETHYLAMINO)PHENYL)-6-METHYL-BENZOTHIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4'-(DIMETHYLAMINO)PHENYL)-6-METHYL-BENZOTHIAZOLE(10205-62-6)
• EPA Substance Registry System: 2-(4'-(DIMETHYLAMINO)PHENYL)-6-METHYL-BENZOTHIAZOLE(10205-62-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• Hazardous Substances Data: 10205-62-6(Hazardous Substances Data)

Usage

Description

2-(4'-(DIMETHYLAMINO)PHENYL)-6-METHYL-BENZOTHIAZOLE is an uncharged derivative of Thioflavin-T, a fluorescent dye commonly used in the detection and analysis of amyloid fibrils.

Uses

Used in Biochemistry Research:
2-(4'-(DIMETHYLAMINO)PHENYL)-6-METHYL-BENZOTHIAZOLE is used as a fluorescent probe for the detection and analysis of amyloid fibrils, which are protein aggregates associated with various neurodegenerative diseases such as Alzheimer's and Parkinson's.
Used in Drug Discovery:
2-(4'-(DIMETHYLAMINO)PHENYL)-6-METHYL-BENZOTHIAZOLE is used as a potential therapeutic agent in the development of drugs targeting amyloid-related diseases, due to its ability to bind and stabilize amyloid fibrils, potentially inhibiting their formation and toxicity.
Used in Diagnostic Imaging:
2-(4'-(DIMETHYLAMINO)PHENYL)-6-METHYL-BENZOTHIAZOLE is used as a contrast agent in diagnostic imaging techniques, such as fluorescence microscopy and positron emission tomography (PET), to visualize and monitor the presence and progression of amyloid deposits in vivo.

InChI:InChI=1/C16H16N2S/c1-11-4-9-14-15(10-11)19-16(17-14)12-5-7-13(8-6-12)18(2)3/h4-10H,1-3H3

Upstream product

• 2390-54-7 thioflavine T 
• 917-54-4 methyllithium 
• 346691-88-1 4-(6-bromobenzo[d]thiazol-2-yl)-N,N-dimethylaniline 
• 619-84-1 p-N,N-dimethylaminobenzoic acid 
• 23451-95-8 2-amino-5-bromobenzenethiol 
• 106-49-0 p-toluidine 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 4755-50-4 4-(dimethylamino)benzoyl chloride 
• 23451-96-9 2-amino-5-methylthiophenol 
• 67-56-1 methanol 
• 92-36-4 2-(4-aminophenyl)-6-methyl-1,3-benzothiazole 
• 16862-65-0 N,N,N-trimethyl-4-(6-methyl-benzothiazol-2-yl)-anilinium; chloride 
• 74-88-4 methyl iodide 

Downstream Products

• 21223-63-2 2-(4-dimethylamino-phenyl)-3,6-dimethyl-benzothiazolium; 3,3'-dihydroxy-4,4'-methanediyl-bis-naphthalene-2-carboxylate (embonate, pamoate) (2:1) 
• 21223-62-1 2-(4-dimethylamino-phenyl)-3,6-dimethyl-benzothiazolium; 3-hydroxy-naphthalene-2-carboxylate 
• 2390-54-7 thioflavine T 

Relevant articles and documents

Cross-coupling of [11C]methyllithium for 11C-labelled PET tracer synthesis

The cross-coupling of aryl bromides with [11C]CH3Li for the labelling of a variety of tracers for positron emission tomography (PET) is presented. The radiolabelled products were obtained in excellent yields, at rt and after short reaction times (3-5 min) compatible with the half-life of 11C (20.4 min). The automation of the protocol on a synthesis module is investigated, representing an important step towards a fast method for the synthesis of 11C-labelled compounds for PET imaging. This journal is

A convenient method for synthesis of benzo[d]thiazoles in water and solvent free condition

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