102394-34-3

Basic information

• Product Name: Benzoxazole, 5-chloro-2-(phenylmethyl)-
• CAS NO: 102394-34-3
• Molecular Formula: C14H10ClNO
• Molecular Weight: 243.692
• Mol File: 102394-34-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzoxazole, 5-chloro-2-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoxazole, 5-chloro-2-(phenylmethyl)-(102394-34-3)
• EPA Substance Registry System: Benzoxazole, 5-chloro-2-(phenylmethyl)-(102394-34-3)

Safety Data

• Hazardous Substances Data: 102394-34-3(Hazardous Substances Data)

Upstream product

• 100-42-5 styrene 
• 95-85-2 2-hydroxy-5-chloro-aniline 
• 98-86-2 acetophenone 
• 621-82-9 Cinnamic acid 
• 100-44-7 benzyl chloride 
• 17200-29-2 5-chloro-benzoxazole 
• 122-78-1 phenylacetaldehyde 
• 13326-10-8 benzyl methyl carbonate 
• 86886-76-2 N-(5-Chloro-2-hydroxy-phenyl)-2-phenyl-acetamide 

Downstream Products

• 32729-66-1 (5-chlorobenzo[d]oxazol-2-yl)(phenyl)methanone 

Relevant articles and documents

Elemental Sulfur-Promoted Benzoxazole/Benzothiazole Formation Using a C=C Double Bond as a One-Carbon Donator

An efficient method to assemble diverse benzoxazoles/benzothiazoles in good yields was developed via oxidative cyclization with 2-aminothiophenols or 2-iodoanilines as raw materials. In this protocol, elemental sulfur was used as the effective oxidant and C atoms on the C=C double bond were introduced as a one-carbon donator.

Elemental sulfur mediated synthesis of benzoxazoles, benzothiazoles and quinoxalines: Via decarboxylative coupling of 2-hydroxy/mercapto/amino-anilines with cinnamic acids

An easy and practical method has been developed for the synthesis of 2-benzylbenzoxazoles and 2-benzylbenzothiazoles using sulfur mediated decarboxylative coupling of cinnamic acids with 2-hydroxyanilines and 2-mercaptoanilines respectively under metal- and solvent-free conditions. However, the reaction of 2-aminoanilines with cinnamic acids leads to the formation of 2-arylquinoxalines under the same set of reaction conditions. The transformation is versatile and compatible with a number of functional groups.

An efficient synthesis of 2-substituted benzoxazoles via RuCl 3·3H2O catalyzed tandem reactions in ionic liquid

An efficient synthesis of 2-substituted benzoxazoles through RuCl 3·3H2O catalyzed, air oxidized tandem reactions of 2-aminophenols and aldehydes in [bmim]BF4 was developed. This synthetic strategy has such advantages as mild reaction conditions, cost-free oxidant, readily available starting materials, and recyclable catalyst and solvent. As an application, it was successfully used in the synthesis of the unreported 5-(benzoxazol-2-yl)-2′-deoxyuridines with potential biological activities. A novel and efficient synthesis of 2-substituted benzoxazoles through RuCl3 catalyzed, air oxidized tandem reactions of 2-aminophenols and aldehydes in [bmim]BF4 was developed.