1026010-24-1

Basic information

• Product Name: 3-(5-p-tolyl-thiophen-2-yl)-acryloyl chloride
• CAS NO: 1026010-24-1
• Molecular Weight: 262.76
• Mol File: 1026010-24-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(5-p-tolyl-thiophen-2-yl)-acryloyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(5-p-tolyl-thiophen-2-yl)-acryloyl chloride(1026010-24-1)
• EPA Substance Registry System: 3-(5-p-tolyl-thiophen-2-yl)-acryloyl chloride(1026010-24-1)

Safety Data

• Hazardous Substances Data: 1026010-24-1(Hazardous Substances Data)

Upstream product

• 229007-97-0 (E)-3-[5-(4-methylphenyl)-thiophen-2-yl]acrylic acid 
• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 38401-68-2 5-(4-methylphenyl)thiophene-2-carbaldehyde 
• 5720-05-8 4-methylphenylboronic acid 

Relevant articles and documents

Structure-activity relationships of novel anti-malarial agents part 8. Effect of different central aryls in biarylacryloylaminobenzophenones on antimalarial activity

Replacement of the 2,5-disubstituted furyl residue present in the known antimalarial agents 8 by other aryl residues resulted in a more or less reduced antimalarial activity in most cases. The only exemption was the 2,4-thienylene compound 11a displaying activity with an IC50 value of 120 nM. In conclusion, the 2,5-furylene compound 8e remains to represent the most active antimalarial agent in this series of farnesyltransferase inhibitors.