229007-97-0

Basic information

• Product Name: 2-Propenoic acid, 3-[5-(4-methylphenyl)-2-thienyl]-, (2E)-
• CAS NO: 229007-97-0
• Molecular Formula: C14H12O2S
• Molecular Weight: 244.314
• Mol File: 229007-97-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-[5-(4-methylphenyl)-2-thienyl]-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-[5-(4-methylphenyl)-2-thienyl]-, (2E)-(229007-97-0)
• EPA Substance Registry System: 2-Propenoic acid, 3-[5-(4-methylphenyl)-2-thienyl]-, (2E)-(229007-97-0)

Safety Data

• Hazardous Substances Data: 229007-97-0(Hazardous Substances Data)

Upstream product

• 14643-62-0 tris(p-methylphenyl) borate 
• 62157-62-4 3-(5'-bromothiophen-2'-yl)-(E)-propenoic acid methyl ester 
• 5720-05-8 4-methylphenylboronic acid 
• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 

Downstream Products

• 229005-41-8 (E)-N-[4-[N-methyl-N-(tetrahydropyran-4-yl)aminomethyl]phenyl]-3-[5-(4-methylphenyl)thiophen-2-yl]-acrylic amide 
• 1026010-24-1 3-(5-p-tolyl-thiophen-2-yl)-acryloyl chloride 

Relevant articles and documents

Structure-activity relationships of novel anti-malarial agents part 8. Effect of different central aryls in biarylacryloylaminobenzophenones on antimalarial activity

Replacement of the 2,5-disubstituted furyl residue present in the known antimalarial agents 8 by other aryl residues resulted in a more or less reduced antimalarial activity in most cases. The only exemption was the 2,4-thienylene compound 11a displaying activity with an IC50 value of 120 nM. In conclusion, the 2,5-furylene compound 8e remains to represent the most active antimalarial agent in this series of farnesyltransferase inhibitors.