1026078-41-0

Basic information

• Product Name: C₃₄H₃₁O₄S₂N₃
• Synonyms: C₃₄H₃₁O₄S₂N₃
• CAS NO: 1026078-41-0
• Molecular Weight: 609.77
• Mol File: 1026078-41-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₄H₃₁O₄S₂N₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₄H₃₁O₄S₂N₃(1026078-41-0)
• EPA Substance Registry System: C₃₄H₃₁O₄S₂N₃(1026078-41-0)

Safety Data

• Hazardous Substances Data: 1026078-41-0(Hazardous Substances Data)

Upstream product

• 74687-21-1 5-isopropylthiobarbituric acid 
• 759-36-4 diethyl isopropylmalonate 
• 1026717-79-2 C₁₅H₁₈O₃SN₂ 
• 132-75-2 naphthalen-1-ylacetonitrile 
• 1026494-93-8 C₂₉H₃₀O₇S₃N₂ 

Relevant articles and documents

Synthesis and anti-HIV-1 activity evaluation of 5-alkyl-2-alkylthio-6- (arylcarbonyl or α-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

A series of novel S-DABO analogues (S-DABOs, 1) were synthesized and evaluated as inhibitors of human immunodeficiency virus type-1 (HIV-1). Key structural modifications included replacement of the 6-arylmethyl group by a 6-arylcarbonyl or 6-(α-cyanoarylmethyl) group. Most of the compounds showed only micromolar potency against HIV-1 in MT-4 cells in vitro, though two of them (3e and 3g) were unusually potent (IC50 = 0.09 and 0.002 μM, respectively) and selective (SI = 1500 and 4600, respectively). Structure-activity relationships among the newly synthesized S-DABOs are discussed.