102842-51-3 Usage
Description
3-Oxo Ropinirole (Ropinirole Impurity C) is a chemical compound that is an impurity of Ropinirole, a medication used to treat Parkinson's disease and restless legs syndrome. It is potentially formed during the synthesis of Ropinirole and has been identified as a related impurity.
Uses
Used in Pharmaceutical Industry:
3-Oxo Ropinirole (Ropinirole Impurity C) is used as a reference standard for quality control and assurance in the synthesis and manufacturing process of Ropinirole. It helps in the identification, quantification, and control of impurities in the final drug product, ensuring its safety, efficacy, and purity.
Used in Research and Development:
3-Oxo Ropinirole (Ropinirole Impurity C) is used as a research tool in the study of the synthesis, metabolism, and pharmacological properties of Ropinirole. It aids in understanding the structure-activity relationship, potential side effects, and mechanisms of action of the drug.
Used in Regulatory Compliance:
3-Oxo Ropinirole (Ropinirole Impurity C) is used in the development and validation of analytical methods for the detection and quantification of impurities in Ropinirole. It helps in meeting the regulatory requirements for drug approval and post-marketing surveillance.
Used in Antihypertensive and Antianginal Applications:
Although primarily an impurity, 3-Oxo Ropinirole (Ropinirole Impurity C) has been reported to have potential use as an antihypertensive and antianginal agent. Further research and development may explore its therapeutic potential in the treatment of hypertension and angina.
Check Digit Verification of cas no
The CAS Registry Mumber 102842-51-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,2,8,4 and 2 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 102842-51:
(8*1)+(7*0)+(6*2)+(5*8)+(4*4)+(3*2)+(2*5)+(1*1)=93
93 % 10 = 3
So 102842-51-3 is a valid CAS Registry Number.
102842-51-3Relevant articles and documents
Development and validation of Ropinirole hydrochloride and its related compounds by UPLC in API and pharmaceutical dosage forms
Krishnaiah,Murthy, M. Vishnu,Reddy, A. Raghupathi,Kumar, Ramesh,Mukkanti
experimental part, p. 348 - 355 (2011/04/22)
A novel stability-indicating gradient reverse phase ultra performance liquid chromatographic (RP-UPLC) method was developed for the determination of purity of Ropinirole in presence of its impurities and forced degradation products. The method was developed using Waters Aquity BEH 100 mm, 2.1 mm, 1.7 μm C-8 column with mobile phase containing a gradient mixture of solvent A and B. The eluted compounds were monitored at 250 nm. The run time was within 4.5 min which Ropinirole and its four impurities were well separated. Ropinirole was subjected to the stress conditions of oxidative, acid, base, hydrolytic, thermal and photolytic degradation. Ropinirole was found to degrade significantly in oxidative and base stress conditions and stable in acid, water, hydrolytic and photolytic degradation conditions. The degradation products were well resolved from main peak and its impurities, thus proved the stability indicating power of the method. The developed method was validated as per International Conference on Harmonization (ICH) guidelines with respect to specificity, linearity, limit of detection, limit of quantification, accuracy, precision and robustness. This method was also suitable for the assay determination of Ropinirole in pharmaceutical dosage forms and dissolution studies.
