103259-94-5

Basic information

• Product Name: <2R>-2-Isopropenyl-cyclopropan-1,1-dicarbonsaeure-bis(<1R,2S,5R>-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl)ester
• CAS NO: 103259-94-5
• Molecular Weight: 598.866
• Mol File: 103259-94-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: <2R>-2-Isopropenyl-cyclopropan-1,1-dicarbonsaeure-bis(<1R,2S,5R>-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl)ester(CAS DataBase Reference)
• NIST Chemistry Reference: <2R>-2-Isopropenyl-cyclopropan-1,1-dicarbonsaeure-bis(<1R,2S,5R>-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl)ester(103259-94-5)
• EPA Substance Registry System: <2R>-2-Isopropenyl-cyclopropan-1,1-dicarbonsaeure-bis(<1R,2S,5R>-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl)ester(103259-94-5)

Safety Data

• Hazardous Substances Data: 103259-94-5(Hazardous Substances Data)

Upstream product

• 66323-16-8 -4-Brom-1-chlor-2-methyl-2-buten 
• 75863-05-7 Bis<(1S,2R,4R)-2-methyl-5-(1-methyl-1-phenylethyl)cyclohexyl>malonate 
• 18860-95-2 1,4-dibromo-2-methylbut-2-ene 

Relevant articles and documents

Total Synthesis of the Pseudoguaianolide (+)-Confertin

The first total synthesis of the pseudoguaianolide (+)-confertin (1) begins with the preparation of the enantiomerically pure cyclopropane derivative 6b and its stereospecific ring expansion furnishing the five-membered ring A-building block 8a.The AB ketone 21d is produced by intermolecular Michael addition, Lewis acid catalyzed intramolecular hetero-ene reaction, and a pair of oxidation/reduction reactions.Fusion of the heterocyclic five-membered ring and α-methylenation of the ABC intermediate 35c is accomplished by well-known technology.The structure of essential synthetic intermediates has been determined by 2D-NMR, CD spectroscopy, or single crystal X-ray analysis.The whole synthesis starts from α-chloroacetone and reaches the target compound 1 after 22 steps.