103290-40-0

Basic information

• Product Name: (2S,4R)-4-PHENYLPYRROLIDINE-2-CARBOXYLIC ACID
• Synonyms: (2S,4R)-4-PHENYLPYRROLIDINE-2-CARBOXYLIC ACID;(4R)-4-Phenyl-L-proline;cis-4-Phenyl-L-proline
• CAS NO: 103290-40-0
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.229
• Mol File: 103290-40-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 372.8 °C at 760 mmHg
• Flash Point: 179.3 °C
• Appearance: /
• Density: 1.186
• Vapor Pressure: 3.22E-06mmHg at 25°C
• Refractive Index: 1.562
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (2S,4R)-4-PHENYLPYRROLIDINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-4-PHENYLPYRROLIDINE-2-CARBOXYLIC ACID(103290-40-0)
• EPA Substance Registry System: (2S,4R)-4-PHENYLPYRROLIDINE-2-CARBOXYLIC ACID(103290-40-0)

Safety Data

• Hazardous Substances Data: 103290-40-0(Hazardous Substances Data)

Usage

General Description

(2S,4R)-4-Phenylpyrrolidine-2-carboxylic acid is a chemical compound belonging to the pyrrolidine and carboxylic acid families. It is a chiral molecule, meaning it has a non-superimposable mirror image. (2S,4R)-4-PHENYLPYRROLIDINE-2-CARBOXYLIC ACID has potential applications in the synthesis of pharmaceuticals and agrochemicals due to its unique structure and reactivity. It may also be used as a building block in organic synthesis, particularly in the creation of new chemical entities for drug discovery and development. Additionally, the phenyl group in its structure confers certain properties that may make it suitable for use in materials science and other industrial applications.

InChI:InChI=1/C11H13NO2/c13-11(14)10-6-9(7-12-10)8-4-2-1-3-5-8/h1-5,9-10,12H,6-7H2,(H,13,14)/t9-,10-/m0/s1

Upstream product

• 99859-73-1 3-chloro-5-phenyl-piperidin-2-one 
• 64-17-5 ethanol 
• 7732-18-5 water 
• 3973-63-5 5-phenylpiperidin-2-one 
• 78464-03-6 N-(benzyloxycarbonyl)-cis-4-hydroxy-trans-4-phenyl-L-proline 
• 336818-78-1 (2S,4R)-1-(tert-butoxycarbonyl)-4-phenyl-2-pyrrolidinecarboxylic acid 
• 64187-47-9 1-benzyloxycarbonyl-4-keto-L-proline 
• 591-51-5 phenyllithium 
• 57653-38-0 N-<(phenylmethoxy)carbonyl>-4(R)-<<(4-methylphenyl)sulfonyl>oxy>-(S)-proline methyl ester 
• 82087-66-9 N-(benzyloxycarbonyl)-3,4-dehydro-4-phenyl-L-proline 
• 99854-36-1 3,3-dichloro-5-phenyl-piperidin-2-one 

Downstream Products

• 1093651-96-7 (2S,4R)-1-(tert-butoxycarbonyl)-4-phenylpyrrolidine-2-carboxylic acid 
• 83624-19-5 (2S,4R)-4-Cyclohexyl-1-{2-[ethoxy-(4-phenyl-butyl)-phosphinoyl]-acetyl}-pyrrolidine-2-carboxylic acid 
• 83624-20-8 (2S,4R)-4-Cyclohexyl-1-{2-[hydroxy-(4-phenyl-butyl)-phosphinoyl]-acetyl}-pyrrolidine-2-carboxylic acid 
• 83624-30-0 (2S,4R)-1-{2-[Hydroxy-(4-phenyl-butyl)-phosphinoyl]-acetyl}-4-phenyl-pyrrolidine-2-carboxylic acid 
• 785001-74-3 cis-4-cyclohexyl-L-proline 

Relevant articles and documents

Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions

The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.

LITHIUM DIPHENYLCUPRATE REACTIONS WITH 4-TOSYLOXY-L-PROLINES; AN INTERESTING STEREOCHEMICAL OUTCOME. A SYNTHESIS OF TRANS-4-PHENYL-L-PROLINE.

The reaction of lithium diphenylcuprate with trans-4- and cis-4-tosyloxy-L-prolines gives excellent yields of 4-phenyl substituted L-prolines and the reaction proceeds with net retention of configuration at the carbon center bearing the tosyloxy group.