1033194-57-8

Basic information

• Product Name: Tert-Butyl 1-(Hydroxyimino)-3-Phenylpropan-2-Ylcarbamate
• Synonyms: Tert-Butyl 1-(Hydroxyimino)-3-Phenylpropan-2-Ylcarbamate
• CAS NO: 1033194-57-8
• Molecular Formula: C14H20N2O3
• Molecular Weight: 264.3202
• Mol File: 1033194-57-8.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Tert-Butyl 1-(Hydroxyimino)-3-Phenylpropan-2-Ylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: Tert-Butyl 1-(Hydroxyimino)-3-Phenylpropan-2-Ylcarbamate(1033194-57-8)
• EPA Substance Registry System: Tert-Butyl 1-(Hydroxyimino)-3-Phenylpropan-2-Ylcarbamate(1033194-57-8)

Safety Data

• Hazardous Substances Data: 1033194-57-8(Hazardous Substances Data)

Upstream product

• 103127-53-3 N-tert-butyloxycarbonyl-2-amino-3-phenylpropionaldehyde 
• 66605-57-0 (S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 63-91-2 L-phenylalanine 
• 72155-45-4 Boc-L-phenylalaninal 
• 77119-85-8 N-(tert-butoxycarbonyl)-D-phenylalaninal 
• 251325-80-1 [1-(hydroxyimino-methyl)-2-phenyl-vinyl]-carbamic acid tert-butyl ester 
• 51987-73-6 (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester 

Downstream Products

• 1311399-84-4 C₁₇H₂₀N₂O₅ 
• 145625-20-3 3-<(1S)-N-(tert-butyloxycarbonyl)amino-2-phenylethyl>-5-<(2R)-(bornane-10,2-sultamyl)-N-carbonyl>-(5R)-Δ²-isoxazoline 
• 145679-60-3 {(S)-1-[(S)-5-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-4,5-dihydro-isoxazol-3-yl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester 

Relevant articles and documents

Tetrahydro-4 H-(pyrrolo[3,4- d]isoxazol-3-yl)methanamine: A Bicyclic Diamino Scaffold Stabilizing Parallel Turn Conformations

A tetrahydro-4H-(pyrrolo[3,4-d]isoxazol-3-yl)methanamine scaffold was designed as a diamino derivative to stabilize parallel turn conformations. Its synthesis took advantage of a [1,3]-dipolar cycloaddition reaction between the nitrile oxide derived from

Synthesis of Enantiomerically Pure N-Acyl Amino Nitriles via Catalytic Dehydration of Oximes and Application in a de Novo Synthesis of Vildagliptin

An alternative route toward enantiomerically highly enriched N-acyl amino nitriles based on the Cu(OAc)2-catalyzed dehydration of aldoximes, which are readily available from N-acyl l- or d-α-amino aldehydes through condensation with hydroxylamine, has been developed. The desired products were obtained with high conversion and in enantiomeric excesses of 97-99% ee. Furthermore, this method has been applied in the synthesis of an N-chloroacetylated 2-cyanopyrrolidine, which represents a building block for the synthesis of Vildagliptin.

A facile one-pot synthesis of Nα-urethane protected 3-amino alkyl isoxazole-5-carboxylic acids and their utility for the preparation of isoxazole-linked peptidomimetics

Cu(I) catalyzed [3+2] cycloaddition of in situ generated N α-Fmoc/Boc/Z-protected amino alkyl nitrile oxide with propiolic acid has led to a new class of 3,5-disubstituted isoxazole-bearing amino acid derivatives. The click chemistry protocol described herein is efficient in furnishing the isoxazole embedded amino acids. These unnatural synthons were subjected to chain extension on N- as well as C-termini to obtain 3,5-disubstituted isoxazole bearing di and tripeptidomimetics. Springer Science+Business Media, LLC 2011.