103361-99-5

Basic information

• Product Name: 7-FLUORO-2H-1,4-BENZOXAZIN-3(4H)-ONE
• Synonyms: 7-FLUORO-2H-1,4-BENZOXAZIN-3(4H)-ONE;7-FLUORO-2,4-DIHYDRO-1,4-BENZOXAZIN-3-ONE;7-FLUORO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE;3-Oxo-7-fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazine;7-Fluoro-4H-benzo[1,4]oxazin-3-one;7-fluoro-3,4-dihydro-2H-1,4-benzoxazin-3-one;3,4-Dihydro-7-fluoro-3-oxo-2H-1,4-benzoxazine, 7-Fluoro-4H-benzo[b][1,4]oxazin-3-one;7-Fluoro-2H-benzo[b][1,4]oxazin-3(4H)
• CAS NO: 103361-99-5
• Molecular Formula: C₈H₆FNO₂
• Molecular Weight: 167.14
• Product Categories: Heterocycles
• Mol File: 103361-99-5.mol
• Article Data: 30

Chemical Properties

• Melting Point: 203-205°
• Boiling Point: 327.871 °C at 760 mmHg
• Flash Point: 152.091 °C
• Appearance: /
• Density: 1.347
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 7-FLUORO-2H-1,4-BENZOXAZIN-3(4H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-FLUORO-2H-1,4-BENZOXAZIN-3(4H)-ONE(103361-99-5)
• EPA Substance Registry System: 7-FLUORO-2H-1,4-BENZOXAZIN-3(4H)-ONE(103361-99-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 103361-99-5(Hazardous Substances Data)

Usage

General Description

7-Fluoro-2H-1,4-benzoxazin-3(4H)-one is a chemical compound with the formula C8H5FNO2. It is a derivative of benzoxazine and contains a fluorine atom at the 7 position. 7-Fluoro-2H-1,4-benzoxazin-3(4H)-one has been studied for its potential biological activities, including its anti-inflammatory and cytotoxic properties. It has also been investigated for its potential use in agrochemical applications due to its role in plant defense mechanisms. The synthesis and characterization of 7-Fluoro-2H-1,4-benzoxazin-3(4H)-one have been the subject of scientific research to better understand its properties and potential applications.

Upstream product

• 116355-65-8 methyl 2-(5-fluoro-2-nitro-phenoxy)acetate 
• 103362-07-8 ethyl 2-(5-fluoro-2-nitrophenoxy)acetate 
• 7439-89-6 iron 
• 53981-24-1 2-amino-5-fluorophenol 
• 446-35-5 2,4-Difluoronitrobenzene 
• 446-36-6 5-fluoro-2-nitrophenol 
• 1183246-92-5 2-(5-fluoro-2-nitrophenoxy)acetonitrile 
• 79-04-9 chloroacetyl chloride 
• 96-34-4 methyl chloroacetate 
• 367-25-9 2,4-difluorophenylamine 
• 137472-06-1 2-chloro-N-(4-fluoro-2-hydroxyphenyl)acetamide 

Downstream Products

• 103361-67-7 7-fluoro-3,4-dihydro-3-oxo-6-nitro-2H-1,4-benzoxazine 
• 56346-41-9 7-fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazine 
• 355423-58-4 6-bromo-7-fluoro-4H-benzo[1,4]oxazin-3-one 
• 1610610-83-7 4-(5-(1-(7-fluoro-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)ethyl)pyrazolo[1,5-a]pyridin-3-yl)benzamide 
• 1610610-90-6 4-(5-(7-fluoro-3-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-4-carbonyl)pyrazolo[1,5-a]pyridin-3-yl)-N-methylbenzamide 
• 61382-42-1 7-fluoro-3-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine 
• 112748-06-8 7-fluoro-6-amino-2H-1,4-benzoxazin-3-(4H)-one 
• 1040236-27-8 4-benzyl-7-fluoro-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1613720-59-4 3-(4-methyl-3-oxo-7-phenoxy-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triazaphenanthren-6-ylamino)azetidine-1-carboxylic acid tert-butyl ester 
• 1613720-58-3 6-amino-4-methyl-7-phenoxy-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one 
• 1613720-57-2 4-methyl-6-nitro-7-phenoxy-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one 
• 1613720-40-3 6-(1-benzhydryl-3-methylazetidin-3-ylamino)-7-fluoro-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one 

Relevant articles and documents

Synthesis, docking, 3-D-qsar, and biological assays of novel indole derivatives targeting serotonin transporter, dopamine D2 receptor, and mao-a enzyme: In the pursuit for potential multitarget directed ligands

A series of 27 compounds of general structure 2,3-dihydro-benzo[1,4]oxazin-4-yl)-2-{4-[3-(1H-3indolyl)-propyl]-1-piperazinyl}-ethanamides, Series I: 7(a-o) and (2-{4-[3-(1H-3-indolyl) -propyl]-1-piperazinyl}-acetylamine)-N-(2-morfolin-4-yl-ethyl)-fluorinated benzamides Series II: 13(a-l) were synthesized and evaluated as novel multitarget ligands towards dopamine D2 receptor, serotonin transporter (SERT), and monoamine oxidase-A (MAO-A) directed to the management of major depressive disorder (MDD). All the assayed compounds showed affinity for SERT in the nanomolar range, with five of them displaying Ki values from 5 to 10 nM. Compounds 7k, Ki = 5.63 ± 0.82 nM, and 13c, Ki = 6.85 ± 0.19 nM, showed the highest potencies. The affinities for D2 ranged from micro to nanomolar, while MAO-A inhibition was more discrete. Nevertheless, compounds 7m and 7n showed affinities for the D2 receptor in the nanomolar range (7n: Ki = 307 ± 6 nM and 7m: Ki = 593 ± 62 nM). Compound 7n was the only derivative displaying comparable affinities for SERT and D2 receptor (D2/SERT ratio = 3.6) and could be considered as a multitarget lead for further optimization. In addition, docking studies aimed to rationalize the molecular interactions and binding modes of the designed compounds in the most relevant protein targets were carried out. Furthermore, in order to obtain information on the structure-activity relationship of the synthesized series, a 3-D-QSAR CoMFA and CoMSIA study was conducted and validated internally and externally (q2 = 0.625, 0.523 for CoMFA and CoMSIA and r2ncv = 0.967, 0.959 for CoMFA and CoMSIA, respectively).

TETRALIN AND TETRAHYDROQUINOLINE COMPOUNDS AS INHIBITORS OF HIF-2ALPHA

Compounds that inhibit HIF-2a, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases dis

Design, Herbicidal Activity, and QSAR Analysis of Cycloalka[ d]quinazoline-2,4-dione-Benzoxazinones as Protoporphyrinogen IX Oxidase Inhibitors

In continuation of our search for potent protoporphyrinogen IX oxidase (PPO, EC 1.3.3.4) inhibitors, we designed and synthesized a series of novel herbicidal cycloalka[d]quinazoline-2,4-dione-benzoxazinones. The bioassay results of these synthesized compo