116355-65-8Relevant articles and documents
Synthesis and biological evaluation of prodrugs for nitroreductase based 4-β-amino-4′-Demethylepipodophyllotoxin as potential anticancer agents
Deng, Wei,He, Dian,Wu, Zheng-Rong
, (2022/01/31)
A series of prodrugs for nitroreductase (NTR) based 4-β-amino-4′- Demethylepipodophyllotoxin as potential anticancer agents were synthesized, and their antiproliferative activities in vitro showed compounds 2b (IC50 = 0.77, 0.83 and 1.19 μM) an
Method for synthetizing 2-(5-fluorine-2-nitryl-phenoxyl) methyl acetate
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Paragraph 0024; 0026; 0034-0037, (2018/04/01)
The invention discloses a method for synthetizing 2-(5-fluorine-2-nitryl-phenoxyl) methyl acetate. According to the method, 2,4-difluoronitrobenzene is used as raw materials; the 2-(5-fluorine-2-nitryl-phenoxyl) methyl acetate (a flumioxazin intermediate) is obtained through hydroxy substitution and etherification reaction. The synthesis method provided by the invention has the advantages that the 2,4-difluoronitrobenzene is used as raw materials; the price is low; the obtaining is easy, so that the production cost is reduced to a certain degree; the intermediate 1 directly reacts with methyl chloroacetate; the operation is simple; the raw materials can be repeatedly used, so that the production cost is reduced; through etherification reaction, byproducts of hydrochloric acid are recovered; no byproducts of sylvite are generated; environment-friendly and green effects are achieved; the aftertreatment operation is simple and convenient; in addition, the raw materials are cheap and can be easily obtained; the reaction condition are mild; the operation is simple and convenient; the popularization to scale production is favorably realized.
Herbicidal glutarimides
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, (2008/06/13)
This invention relates to glutarimide compounds exhibiting herbicidal activity having the structure STR1 wherein A is carbonyl, thiocarbonyl or methylene, A1 is carbonyl or methylene, Q is O or (CH2)n where n is 0 or 1, D is CH or N and R, R1, R2, T, X, Y and Z are as defined within, compositions containing these compounds and methods of using these compounds as herbicides and algicides.