10342-66-2

Basic information

• Product Name: Benzene, 4-bromo-1-ethyl-2-nitro-
• CAS NO: 10342-66-2
• Molecular Formula: C8H8BrNO2
• Molecular Weight: 230.061
• Mol File: 10342-66-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzene, 4-bromo-1-ethyl-2-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 4-bromo-1-ethyl-2-nitro-(10342-66-2)
• EPA Substance Registry System: Benzene, 4-bromo-1-ethyl-2-nitro-(10342-66-2)

Safety Data

• Hazardous Substances Data: 10342-66-2(Hazardous Substances Data)

Upstream product

• 612-22-6 2-nitro(ethylbenzene) 
• 1585-07-5 1-bromo-4-ethylbenzene 
• 589-16-2 4-aminoethylbenzene 

Downstream Products

• 244140-70-3 2-(4-bromo-2-nitrophenyl)propan-1-ol 
• 1142189-49-8 6-bromo-2,3-dimethyl-1H-indazole 
• 1376676-65-1 N,2,3-trimethyl-2H-indazole-6-amine 
• 444731-75-3 N-(2-chloropyrimidin-4-yl)-N-methyl-2,3-dimethyl-2H-indazole-6-amine 
• 1198752-78-1 4-(2',4'-dichloro-4-ethylbiphen-3-yl)-2,2,6,6-tetramethyl-5-phenylsulfanyl-6H-pyran-3-one 
• 1198752-77-0 4-(2',4'-dichloro-4-ethylbiphen-3-yl)-2,2,6,6-tetramethyl-5-ethylsulfanyl-6H-pyran-3-one 
• 1198752-76-9 5-chloro-4-(2',4'-dichloro-4-ethylbiphen-3-yl)-2,2,6,6-tetramethyl-6H-pyran-3-one 
• 1090511-14-0 C₂₃H₂₀ClFO₂ 
• 1090511-04-8 C₂₂H₂₀Cl₂O₂ 
• 1090511-05-9 C₂₃H₂₃ClO₂ 
• 1090511-15-1 C₂₄H₂₃ClO₃ 
• 1090511-13-9 C₂₃H₂₃ClO₂ 
• 1090511-06-0 C₂₁H₂₀ClNO₂ 
• 1090511-01-5 C₂₂H₂₁ClO₂ 

Relevant articles and documents

Preparation method of pazopanib intermediate

The invention provides a preparation method of a pazopanib key intermediate 2,3-dimethyl-N-(2-chloropyrimidin-4-yl)-N-methyl-2H-indazole-6-amine. The method comprises the following steps: by taking 6-halogenated-2,3-dimethyl-2H-indazole as a raw material, conducting reacting to obtain N,2,3-trimethyl-2H-indazole-6-amine; and further carrying out a reaction to obtain the 2,3-dimethyl-N-(2-chloropyrimidin-4-yl)-N-methyl-2H-indazole-6-amine. The method has the advantages of short synthesis route, accessible raw materials, low cost, mild reaction conditions, high safety and high yield, and is suitable for industrial mass production.

AURORA AND FLT3 KINASES MODULATORS

The invention provides a compound having the formula (1) useful as modulator of the activity of Aurora kinases and FLT3 kinases: and salts thereof; wherein: R1 is hydrogen or C1-2 alkyl; and R2, R3 and R4 are the same or different and each is selected from hydrogen, C1-2 alkyl, fluorine, chlorine, C1-2 alkoxy and trifluoromethyl, provided that no more than two of R2, R3 and R4 are other than hydrogen. Also provided are pharmaceutical compositions containing the compounds and their use in medicine, and in particular in the treatment of cancer

Asymmetric hydrovinylation of vinylindoles. A facile route to cyclopenta[g]indole natural products (+)-cis-trikentrin A and (+)-cis-trikentrin B

Vinylindoles undergo Ni(II)-catalyzed asymmetric hydrovinylation under very mild conditions (-78 °C, 1 atm ethylene, 4 mol % catalyst) to give the corresponding 2-but-3-enyl derivatives in excellent yields and enantioselectivities. Hydroboration of the alkene and oxidation to an acid, followed by Friedel-Crafts annulation, gives an indole-annulated cyclopentanone that is a suitable precursor for the syntheses of cis-trikentrins and all known herbindoles. For example, the cyclopentanone from 4-ethyl-7-vinylindole is converted into (+)-cis-trikentin A in four steps (Wittig reaction, alkene isomerization, diastereoselective hydrogenation, and nitrogen deprotection). The previous synthesis of this molecule from (S)-(-)-malic acid involved more than 20 steps and a preparative HPLC separation of diastereomeric intermediates.