1142189-49-8

Basic information

• Product Name: 6-Bromo-2,3-dimethyl-2H-indazole
• Synonyms: 6-Bromo-2,3-dimethyl-2H-indazole;6-BroMo-2,3-diMethyl-2H-i...;6-Bromo-2,3-dimethyl-indazole
• CAS NO: 1142189-49-8
• Molecular Formula: C₉H₉BrN₂
• Molecular Weight: 225.08516
• Mol File: 1142189-49-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 338.9±22.0 °C(Predicted)
• Appearance: /
• Density: 1.53±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 1.24±0.30(Predicted)
• CAS DataBase Reference: 6-Bromo-2,3-dimethyl-2H-indazole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromo-2,3-dimethyl-2H-indazole(1142189-49-8)
• EPA Substance Registry System: 6-Bromo-2,3-dimethyl-2H-indazole(1142189-49-8)

Safety Data

• Hazardous Substances Data: 1142189-49-8(Hazardous Substances Data)

Usage

General Description

6-Bromo-2,3-dimethyl-2H-indazole is a chemical compound with the molecular formula C9H9BrN2. It is a derivative of indazole, which is a heterocyclic aromatic organic compound. 6-Bromo-2,3-dimethyl-2H-indazole has a bromine atom at the 6th position of the indazole ring and two methyl groups at the 2nd and 3rd positions. It is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various other chemical compounds. 6-Bromo-2,3-dimethyl-2H-indazole may also have potential applications in medicinal chemistry and drug development due to its unique structural properties. Overall, 6-Bromo-2,3-dimethyl-2H-indazole is a versatile and important chemical with various research and industrial applications.

Upstream product

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Downstream Products

• 1376676-65-1 N,2,3-trimethyl-2H-indazole-6-amine 
• 444731-75-3 N-(2-chloropyrimidin-4-yl)-N-methyl-2,3-dimethyl-2H-indazole-6-amine 
• 1234616-78-4 2,3-dimethylindazole-6-carboxylic acid 
• 1300586-47-3 2-(1-(4-amino-3-(2,3-dimethyl-2H-indazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-3-(3-fluorophenyl)-4H-chromen-4-one 
• 1300582-62-0 2,3-dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-indazole 

Relevant articles and documents

Preparation method of pazopanib intermediate

The invention provides a preparation method of a pazopanib key intermediate 2,3-dimethyl-N-(2-chloropyrimidin-4-yl)-N-methyl-2H-indazole-6-amine. The method comprises the following steps: by taking 6-halogenated-2,3-dimethyl-2H-indazole as a raw material, conducting reacting to obtain N,2,3-trimethyl-2H-indazole-6-amine; and further carrying out a reaction to obtain the 2,3-dimethyl-N-(2-chloropyrimidin-4-yl)-N-methyl-2H-indazole-6-amine. The method has the advantages of short synthesis route, accessible raw materials, low cost, mild reaction conditions, high safety and high yield, and is suitable for industrial mass production.

GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).