1034592-62-5

Basic information

• Product Name: C₂₆H₁₇Cl₂FN₄O
• CAS NO: 1034592-62-5
• Molecular Weight: 491.352
• Mol File: 1034592-62-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₆H₁₇Cl₂FN₄O(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₆H₁₇Cl₂FN₄O(1034592-62-5)
• EPA Substance Registry System: C₂₆H₁₇Cl₂FN₄O(1034592-62-5)

Safety Data

• Hazardous Substances Data: 1034592-62-5(Hazardous Substances Data)

Upstream product

• 57584-71-1 5-fluoroisoindoline 
• 1034266-31-3 5-(4-chloro-phenyl)-1-(2-chloro-phenyl)-4-cyanomethyl-1H-pyrazole-3-carboxylic acid 

Relevant articles and documents

Exploring SAR features in diverse library of 4-cyanomethyl-pyrazole-3-carboxamides suitable for further elaborations as CB1 antagonists

A chemically diverse library of secondary and tertiary 4-cyanomethyl-1,5-diphenyl-1H-pyrazole-3-carboxamides was synthesized to enable mapping of the SAR, in the eastern amide region, with regard to CB1 antagonist activity, This study was initiated as a prelude to the design and synthesis of possible CB1 antagonists that do not readily pass the blood-brain-barrier. In general a range of modifications were found to be tolerated in this part of the molecule, although polar and especially charged groups did to a degree reduce the CB1 antagonistic activity. Several compounds with single-digit or even sub-nanomolar potency, suitable for further elaboration of the nitrile moiety, were identified.