57584-71-1

Basic information

• Product Name: 5-FLUORO-2,3-DIHYDRO-1H-ISOINDOLE
• Synonyms: 5-FLUORO-2,3-DIHYDRO-1H-ISOINDOLE;5-Fluoro-2,3-dihydro-1H-isoindoleHydrochloride;5-Fluoroisoindoline;5-FLUORO-2,3-DIHYDRO-1H-ISOINDOLE HCL;1H-Isoindole, 5-fluoro-2,3-dihydro-
• CAS NO: 57584-71-1
• Molecular Formula: C₈H₈FN
• Molecular Weight: 137.15
• Product Categories: Pyrroles & Indoles
• Mol File: 57584-71-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 194.4 °C at 760 mmHg
• Flash Point: 71.4 °C
• Appearance: /
• Density: 1.154 g/cm³
• Vapor Pressure: 0.0408mmHg at 25°C
• PKA: 8.86±0.20(Predicted)
• CAS DataBase Reference: 5-FLUORO-2,3-DIHYDRO-1H-ISOINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FLUORO-2,3-DIHYDRO-1H-ISOINDOLE(57584-71-1)
• EPA Substance Registry System: 5-FLUORO-2,3-DIHYDRO-1H-ISOINDOLE(57584-71-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22-51
• Hazardous Substances Data: 57584-71-1(Hazardous Substances Data)

Usage

General Description

5-Fluoro-2,3-dihydro-1H-isoindole is a chemical compound with the molecular formula C8H7FN. It is a fluorinated isoindole derivative and is used in the synthesis of pharmaceutical compounds. It is known for its potential pharmacological activities and is being studied for its potential use in the treatment of various diseases and conditions. The chemical structure of 5-Fluoro-2,3-dihydro-1H-isoindole makes it a versatile compound for potential drug development and research. However, further research and studies are needed to fully understand its pharmacological properties and potential uses.

InChI:InChI=1S/C8H8FN/c9-8-2-1-6-4-10-5-7(6)3-8/h1-3,10H,4-5H2

Upstream product

• 94514-21-3 5-fluoro-isoindole-1,3-dione 
• 319-03-9 4-fluorophthalic anhydride 

Downstream Products

• 871013-94-4 C₁₃H₁₆FNO₂ 
• 1620228-51-4 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl 5-fluoroisoindoline-2-carboxylate 
• 1620228-50-3 4-bromophenyl 5-fluoroisoindoline-2-carboxylate 
• 1664398-52-0 7-chloro-5-(2,4-dimethoxyphenyl)-2-(2-(5-fluoroisoindolin-2-yl)ethyl)[1,2,4]triazolo[1,5-c]quinazoline 
• 1351231-52-1 tert-butyl (S)-4-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)-1-(5-fluoroisoindolin-2-yl)-1,4-dioxobutan-2-ylcarbamate 
• 1351231-54-3 tert-butyl (S)-4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-1-(5-fluoroisoindolin-2-yl)-1,4-dioxobutan-2-ylcarbamate 
• 1240325-50-1 C₃₂H₂₈FNO₃ 
• 1034592-62-5 C₂₆H₁₇Cl₂FN₄O 
• 685565-69-9 N-{4-[(1-cyclobutyl-4-piperidinyl)oxy]benzoyl}-5-fluoroisoindoline 

Relevant articles and documents

Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: Isoindoline containing inhibitors

To obtain selective and potent inhibitors of dipeptidyl peptidases 8 and 9, we synthesized a series of substituted isoindolines as modified analogs of allo-Ile-isoindoline, the reference DPP8/9 inhibitor. The influence of phenyl substituents and different P2 residues on the inhibitors' affinity toward other DPPs and more specifically, their potential to discriminate between DPP8 and DPP9 will be discussed. Within this series compound 8j was shown to be a potent and selective inhibitor of DPP8/9 with low activity toward DPP II.

COMPOUND INHIBITING DIPEPTIDYL PEPTIDASE IV

The invention aims to provide a dipeptidyl peptidase IV inhibitor which is satisfactory in respect of activity, stability and safety and has an excellent action as a pharmaceutical agent. The invention is directed to a compound represented by the following general formula or a pharmaceutically acceptable salt thereof: wherein R1 and R2 each represents hydrogen, an optionally substituted C1-6 alkyl group, or -COOR5 whereupon R5 represents hydrogen or an optionally substituted C1-6 alkyl group, or R1 and R2, together with a carbon atom to which they are bound, represent a 3- to 6-membered cycloalkyl group, R3 represents hydrogen or an optionally substituted C6-10 aryl group, R4 represents a hydrogen or a cyano group, D represents -CONR6-, -CO- or -NR6CO-, R6 represents hydrogen or an optionally substituted C1-6 alkyl group, E represents -(CH2)m- whereupon m is an integer of 1 to 3, -CH2OCH2-, or -SCH2-, n is an integer of 0 to 3, and A represents an optionally substituted bicyclic heterocyclic group or bicyclic hydrocarbon group.