94514-21-3

Basic information

• Product Name: 5-fluoro-1H-Isoindole-1,3(2H)-dione
• Synonyms: 5-fluoro-1H-Isoindole-1,3(2H)-dione;1H-Isoindole-1,3(2H)-dione,5-fluoro-
• CAS NO: 94514-21-3
• Molecular Formula: C₈H₄FNO₂
• Molecular Weight: 165.1212632
• Mol File: 94514-21-3.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-fluoro-1H-Isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-fluoro-1H-Isoindole-1,3(2H)-dione(94514-21-3)
• EPA Substance Registry System: 5-fluoro-1H-Isoindole-1,3(2H)-dione(94514-21-3)

Safety Data

• Hazardous Substances Data: 94514-21-3(Hazardous Substances Data)

Usage

General Description

5-fluoro-1H-Isoindole-1,3(2H)-dione, also known as 5-fluoroisoindolin-1-one, is a chemical compound with the molecular formula C8H4FNO2. It is a heterocyclic organic compound with a fluorine atom attached to the isoindolinone ring. 5-fluoro-1H-Isoindole-1,3(2H)-dione is used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It has also been studied for its potential biological activities, including its anti-inflammatory and anti-cancer properties. 5-fluoro-1H-Isoindole-1,3(2H)-dione has potential applications in the pharmaceutical and agricultural industries due to its unique structure and potential therapeutic properties.

Upstream product

• 700-84-5 5-fluoro-1-indanone 
• 319-03-9 4-fluorophthalic anhydride 
• 77287-34-4 formamide 

Downstream Products

• 57584-71-1 5-fluoroisoindoline 
• 905275-50-5 5-amino-6-fluoro-2,3-dihydro-1H-isoindole-1,3-dione 
• 1354522-16-9 C₁₈H₁₆FNO₄ 
• 1310532-49-0 4-fluoro-2-(2-methyl-2H-1,2,4-triazol-3-yl)benzaldehyde 
• 1310532-47-8 [4-fluoro-2-(2-methyl-2H-1,2,4-triazol-3-yl)phenyl]methanol 
• 1310532-44-5 5-fluoro-2-(2-methyl-2H-1,2,4-triazol-3-yl)benzoic acid methyl ester 
• 1310532-43-4 N-[1(E)-dimethylaminomethylidene]-4-fluorophthalamic acid methyl ester 
• 1310532-42-3 N-[1(E)-dimethylaminomethylidene]-5-fluorophthalamic acid methyl ester 
• 1310532-41-2 4-fluorophthalamic acid methyl ester 
• 1310532-40-1 5-fluorophthalamic acid methyl ester 
• 1310532-39-8 2-tert-butoxycarbonylaminocarbonyl-4-fluorobenzoic acid methyl ester 
• 1310532-38-7 2-tert-butoxycarbonylaminocarbonyl-5-fluorobenzoic acid methyl ester 
• 1310531-03-3 5-{1-tert-butyl-2-[4-fluoro-2-(2-methyl-2H-1,2,4-triazol-3-yl)phenyl]-1H-benzimidazol-5-yl}pyrimidin-2-ylamine 

Relevant articles and documents

Mechanistic Studies on the Organocatalytic α-Chlorination of Aldehydes: The Role and Nature of Off-Cycle Intermediates

Herein we report the isolation and characterization of aminal intermediates in the organocatalytic α-chlorination of aldehydes. These species are stable covalent ternary adducts of the substrate, the catalyst and the chlorinating reagent. NMR-assisted kinetic studies and isotopic labeling experiments with the isolated intermediate did not support its involvement in downstream stereoselective processes as proposed by Blackmond. By tuning the reactivity of the chlorinating reagent, we were able to suppress the accumulation of rate-limiting off-cycle intermediates. As a result, an efficient and highly enantioselective catalytic system with a broad functional group tolerance was developed.

Direct access to cobaltacycles via C-H activation: N-chloroamide- enabled room-temperature synthesis of heterocycles

Cobaltacycle synthesis via C-H activation has been achieved for the first time, providing key mechanistic insight into cobalt catalytic chemistry. NChloroamides are used as a directing synthon for cobalt-catalyzed roomtemperature C-H activation and construction of heterocycles. Alkynes as coupling partners allow convenient access to isoquinolones, a class of synthetically and pharmaceutically important compounds. The broad substrate scope enables a diverse range of substitution patterns to be incorporated into the heterocyclic scaffold.

PYRAZOLOPYRIDINE PYRAZOLOPYRIMIDINE AND RELATED COMPOUNDS

In one aspect this invention relates generally to compounds of Formula: and sub-formulas thereof, or a tautomer of each thereof, a pharmaceutically acceptable salt of each thereof, or a pharmaceutically acceptable solvate of each of the foregoing, where X1, L1, L3, and R3 are described herein.