103594-89-4

Basic information

• Product Name: 4-methoxyphenyltitanium triisopropoxide
• Synonyms: 4-methoxyphenyltitanium triisopropoxide
• CAS NO: 103594-89-4
• Molecular Weight: 332.276
• Mol File: 103594-89-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-methoxyphenyltitanium triisopropoxide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methoxyphenyltitanium triisopropoxide(103594-89-4)
• EPA Substance Registry System: 4-methoxyphenyltitanium triisopropoxide(103594-89-4)

Safety Data

• Hazardous Substances Data: 103594-89-4(Hazardous Substances Data)

Upstream product

• 546-68-9 titanium(IV) isopropylate 
• 20717-86-6 triisopropoxytitanium(IV) chloride 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 699-19-4 4-methoxyphenylmagnesium chloride 
• 696-62-8 para-iodoanisole 

Downstream Products

• 59115-45-6 2-(4-methoxyphenyl)naphthalene 
• 2749-97-5 4-methoxylphenylallene 
• 885588-71-6 5-fluoro-2-(4-methoxyphenyl)pyridine 
• 42545-43-7 2-(4-methoxyphenyl)thiophene 
• 5958-02-1 3-(4-methoxyphenyl)pyridine 
• 5957-90-4 4-(2-pyridinyl)anisole 
• 613-33-2 (4,4'-dimethyl-1,1'-biphenyl) 
• 2132-80-1 4,4'-Dimethoxybiphenyl 

Relevant articles and documents

A general palladium-catalyzed cross-coupling of aryl fluorides and organotitanium (IV) reagents

Pd(OAc)2/1-[2-(di-tert-butylphosphanyl)phenyl]-4-methoxy-piperidine was demonstrated to effectively catalyze cross-coupling of aryl fluoride and aryl(alkyl) titanium reagent. Both electron-deficient and electron-rich aryl fluoride can react effectively with nucleophile and provide extensive functional groups tolerance. 2-Arylated product was realized by selective activation of the C–F bond. Graphic abstract: [Figure not available: see fulltext.].

Catalytic Enantioselective Arylation and Heteroarylation of Ketones with Organotitanium Reagents Generated In Situ

A practical and useful, catalytic enantioselective method has been developed for the synthesis of tertiary diaryl and aryl heteroaryl carbinols starting from commercially available aromatic ketones and aryl or heteroaryl bromides. In this method, organotitanium reagents are generated in situ from the bromides by lithiation with nBuLi followed by transmetallation of the resulting organolithiums with ClTi(OiPr)3. Treatment of the ketones with the titanium reagents in the presence of (R)-3-(3,5-bistrifluoromehthylphenyl)-1,1′-bi-2-naphthol (BTFP-BINOL) affords the corresponding tertiary alcohols in high enantioselectivities and yields. The reaction can also start with furan and 2-thienyllithium. The method is operationally simple and can be conducted on a 10-mmol scale without any difficulties.