1036738-12-1

Basic information

• Product Name: 2,4,6-Trichloro-pyrido[3,2-d]pyrimidine
• Synonyms: 2,4,6-Trichloro-pyrido[3,2-d]pyrimidine
• CAS NO: 1036738-12-1
• Molecular Formula: C₇H₂Cl₃N₃
• Molecular Weight: 234.46988
• Mol File: 1036738-12-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,4,6-Trichloro-pyrido[3,2-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-Trichloro-pyrido[3,2-d]pyrimidine(1036738-12-1)
• EPA Substance Registry System: 2,4,6-Trichloro-pyrido[3,2-d]pyrimidine(1036738-12-1)

Safety Data

• Hazardous Substances Data: 1036738-12-1(Hazardous Substances Data)

Usage

General Description

2,4,6-Trichloro-pyrido[3,2-d]pyrimidine is a chemical compound that belongs to the class of pyrido[3,2-d]pyrimidine derivatives. It is a trichlorinated pyridine-based compound that is often used in the synthesis of pharmaceuticals and agrochemicals. 2,4,6-Trichloro-pyrido[3,2-d]pyrimidine has potential applications as an intermediate in organic synthesis and as a building block in the development of new materials. It may also have biological activity and potential use as a research tool in the study of pyridine-containing compounds. However, due to its chlorinated nature, it may also pose environmental and health hazards and must be handled and used with caution.

Upstream product

• 866807-26-3 methyl 3-amino-6-chloropicolinate 
• 16013-85-7 2,6-dicholoro-3-nitropyridine 
• 93683-65-9 6-chloro-3-nitropicolinonitrile 
• 175358-01-7 3-amino-6-chloro-pyridine-2-carboxylic acid amide 
• 897360-38-2 6-chloropyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione 

Downstream Products

• 1203654-48-1 N-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(6-cyclopropoxypyridin-3-yl)-4-(1-methylcyclopropoxy)pyrido[3,2-d]pyrimidin-2-amine 
• 1318780-07-2 C₂₈H₂₂F₉N₇O₃S 
• 1203653-17-1 4-((4-(1-cyanocyclopropylamino)-6-(6-methoxypyridin-3-yl)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide 
• 1318780-08-3 N₂-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-chloro-N₄-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine 
• 1203654-47-0 N₂-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(6-cyclopropoxypyridin-3-yl)-N₄-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine 
• 1036736-44-3 4-((6-(4-fluorophenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide 
• 1318780-04-9 4-((6-(4-(1H-1,2,4-triazol-1-yl)phenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide 
• 1036738-25-6 4-((6-chloro-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide 
• 1318780-05-0 4-((4-(1-cyanocyclopropylamino)-6-(6-fluoropyridin-3-yl)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide 
• 1318780-06-1 N-(4-(2-(4-sulfamoylbenzylamino)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-6-yl)phenyl)cyclopropanecarboxamide 
• 1036736-85-2 4-{[6-(6-fluoro-pyridin-3-yl)-4-(2,2,2-trifluoro-ethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide 
• 1203652-17-8 4-((6-(4-methoxy-3-(methylsulfonyl)phenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide 
• 1318780-12-9 N-tert-butyl-3-((6-chloro-4-(2,2,2-trifluoroethylamino)pyrido[3,2,d]pyrimidin-2-ylamino)methyl)-5-(trifluoromethyl)benzenesulfonamide 
• 1352577-51-5 C₃₂H₃₀F₉N₇O₃S 

Relevant articles and documents

Preparation method of novel substituted pyridine pyrimidine compound

The invention belongs to the field of pharmaceutical and chemical industry, and provides a preparation method of a novel substituted pyridine pyrimidine compound. The pyridine pyrimidine compound is of great significance to medical research and new drug development. The problem that an amide compound is easily destroyed by strong alkalis in a synthesis process under a high temperature condition issolved, and meanwhile the problem that a pyrimidine 4-amino group is difficult to react to synthesize amide due to poorer amino activity is solved. Moreover, a two-step reaction for reducing a nitrogroup into an amino group and hydrolyzing cyano group into the amide group is completed in a one-step reaction, thereby simplifying the reaction flow. The invention provides a preparation method of the compound. The compound provides important support for the application of the compound in the field of new drug development in the future in terms of synthesis conditions, methods and processes.

QUINAZOLINES AND AZAQUINAZOLINES AS DUAL INHIBITORS OF RAS/RAF/MEK/ERK AND PI3K/AKT/PTEN/MTOR PATHWAYS

The present application provides novel quinazolines and azaquinazolines and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in for co-regulating RAS/RAF/MEK/ERK and PI3K/AKT/PTEN/mTOR pathways by administering a therapeutically effective amount of one or more of the compounds of formula (I), wherein X, Y, T and R4, and R6 to R8' are defined herein, to a patient. By doing so, these compounds are effective in treating conditions associated with the dysregulation of the RAS/RAF/MEK/ERK and PI3K/AKT/PTEN/mTOR pathways. A variety of conditions can be treated using these compounds and include diseases which are characterized by abnormal cellular proliferation. In one embodiment/ the disease is cancer.

2,4,6-TRISUBSTITUTED PYRIDO (3,2-d) PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS

Pyrido(3,2-d)pyrimidine derivatives represented by the structural formuia (Ia): wherein, R1, R2 and R3 are defined herein, pharmaceutical acceptable addition salts, stereochemical isomeric forms, N-oxides, solvates and pro