1037137-45-3

Basic information

• Product Name: C₁₃H₉BrFNO₂
• Synonyms: C₁₃H₉BrFNO₂
• CAS NO: 1037137-45-3
• Molecular Weight: 310.122
• Mol File: 1037137-45-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₃H₉BrFNO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₉BrFNO₂(1037137-45-3)
• EPA Substance Registry System: C₁₃H₉BrFNO₂(1037137-45-3)

Safety Data

• Hazardous Substances Data: 1037137-45-3(Hazardous Substances Data)

Upstream product

• 1003-98-1 2-bromo-4-fluoroaniline 
• 1885-14-9 phenyl chloroformate 

Downstream Products

• 1094562-05-6 N-(2-bromo-4-fluorophenyl)hydrazinecarboxamide 

Relevant articles and documents

Synthesis and biological evaluation of 4-phenoxy-6,7-disubstituted quinolines possessing semicarbazone scaffolds as selective c-Met inhibitors

Novel quinoline derivatives bearing acyclic semicarbazones were prepared and their chemical structures as well as the relative stereochemistry were confirmed. All the synthesized compounds were evaluated for their c-Met kinase inhibitory activity and their cytotoxicity against the cell lines HT-29, MKN-45, and MDA-MB-231 in vitro. Several potent compounds were further evaluated against A549 cells. Most compounds displayed moderate to excellent activity, and the structure-activity relationship studies identified the most promising compound 35 as a selective c-Met kinase inhibitor (IC50 = 4.3 nM). Compound 35 showed a 3.5- and 18.8-fold increase in cytotoxicity in vitro against HT-29 and A549 cells, respectively, compared to that of foretinib. Poor off-target effects of compound 35 were further confirmed by the antiproliferative activity against the c-Met inhibition less sensitive MDA-MB-231 cell line (IC50 = 0.77 μM). Copyright