1037968-21-0

Basic information

• Product Name: C₂₁H₁₇ClF₆N₂O₂
• CAS NO: 1037968-21-0
• Molecular Weight: 478.822
• Mol File: 1037968-21-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₁₇ClF₆N₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₁₇ClF₆N₂O₂(1037968-21-0)
• EPA Substance Registry System: C₂₁H₁₇ClF₆N₂O₂(1037968-21-0)

Safety Data

• Hazardous Substances Data: 1037968-21-0(Hazardous Substances Data)

Upstream product

• 379724-54-6 1-(4-chlorobenzoyl)piperidine-4-carboxylic acid 
• 328-74-5 3,5-Bis-(trifluoromethyl)aniline 

Relevant articles and documents

Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423

We recently identified bis(amide) CCG-1423 (1) as a novel inhibitor of RhoA/C-mediated gene transcription that is capable of inhibiting invasion of PC-3 prostate cancer cells in a Matrigel model of metastasis. An initial structure-activity relationship study focusing on bioisosteric replacement of the amides and conformational restriction identified two compounds, 4g and 8, with improved selectivity for inhibition of RhoA/C-mediated gene transcription and attenuated cytotoxicity relative to 1. Both compounds were also capable of inhibiting cell invasion with equal efficacy to 1 but with less attendant cytotoxicity.