379724-54-6 Usage
General Description
The chemical compound 1-(4-Chloro-benzoyl)-piperidine-4-carboxylic acid is a carboxylic acid derivative containing a piperidine ring and a 4-chlorobenzoyl group. It is commonly used in the field of medicinal chemistry as a building block for the synthesis of various pharmaceutical compounds. 1-(4-Chloro-benzoyl)-piperidine-4-carboxylic acid has potential biological activities and may act as an inhibitor or modulator of certain enzymes or receptors in the body. Its structure and properties make it a valuable tool for the development of new drugs and therapeutic agents. Research on this compound is ongoing, and its potential applications in the pharmaceutical industry continue to be explored.
Check Digit Verification of cas no
The CAS Registry Mumber 379724-54-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,7,9,7,2 and 4 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 379724-54:
(8*3)+(7*7)+(6*9)+(5*7)+(4*2)+(3*4)+(2*5)+(1*4)=196
196 % 10 = 6
So 379724-54-6 is a valid CAS Registry Number.
InChI:InChI=1/C13H14ClNO3/c14-11-3-1-9(2-4-11)12(16)15-7-5-10(6-8-15)13(17)18/h1-4,10H,5-8H2,(H,17,18)
379724-54-6Relevant articles and documents
Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423
Evelyn, Chris R.,Bell, Jessica L.,Ryu, Jenny G.,Wade, Susan M.,Kocab, Andrew,Harzdorf, Nicole L.,Hollis Showalter,Neubig, Richard R.,Larsen, Scott D.
scheme or table, p. 665 - 672 (2010/06/21)
We recently identified bis(amide) CCG-1423 (1) as a novel inhibitor of RhoA/C-mediated gene transcription that is capable of inhibiting invasion of PC-3 prostate cancer cells in a Matrigel model of metastasis. An initial structure-activity relationship study focusing on bioisosteric replacement of the amides and conformational restriction identified two compounds, 4g and 8, with improved selectivity for inhibition of RhoA/C-mediated gene transcription and attenuated cytotoxicity relative to 1. Both compounds were also capable of inhibiting cell invasion with equal efficacy to 1 but with less attendant cytotoxicity.
