1038997-68-0

Basic information

• Product Name: C₂₀H₂₆NO₃P
• Synonyms: C₂₀H₂₆NO₃P
• CAS NO: 1038997-68-0
• Molecular Weight: 359.405
• Mol File: 1038997-68-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: C₂₀H₂₆NO₃P(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₂₆NO₃P(1038997-68-0)
• EPA Substance Registry System: C₂₀H₂₆NO₃P(1038997-68-0)

Safety Data

• Hazardous Substances Data: 1038997-68-0(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 1809-21-8 di-n-propyl phosphonate 
• 92-29-5 hydrobenzamide 

Downstream Products

• 1038997-72-6 C₇H₈O₃S*C₁₃H₂₂NO₃P 
• 1300734-68-2 dipropyl((5-chloro-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamido)(phenyl)methyl)phosphonate 
• 1300734-58-0 dipropyl((5-chloro-1,3-dimethyl-1H-pyrazole-4-carboxamido)-(phenyl)methyl)phosphonate 
• 1300734-63-7 dipropyl((5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamido)(phenyl)methyl)phosphonate 
• 304693-31-0 O,O'-dipropyl {[2-(2,4-dichlorophenoxy)acetamido](phenyl)methyl}phosphonate 
• 1357284-83-3 O,O'-dipropyl {[2-(4-chlorophenoxy)acetamido](phenyl)methyl}phosphonate 
• 1357284-85-5 O,O'-dipropyl {[2-(3-trifluoromethylphenoxy)acetamido](phenyl)methyl}phosphonate 
• 1192761-53-7 C₂₉H₄₃N₄O₃PS₂ 
• 1192761-52-6 C₂₉H₄₃N₄O₃PS₂ 
• 1192761-47-9 C₂₇H₃₉N₄O₃PS₂ 
• 1192761-58-2 O,O'-di-n-propyl isothiocyanato(phenyl)methylphosphonate 

Relevant articles and documents

Synthesis and cytotoxicity of O,O′-dialkyl {[2-(substituted phenoxy)acetamido](substituted phenyl)methyl}phosphonates

A series of O,O′-dialkyl {[2-(substituted phenoxy)acetamido] (substituted phenyl)methyl}phosphonates was synthesized and their cytotoxic activities were tested against various human tumor cell lines. Some compounds (5q, 5r, 5s, 5w, 5x and 5y) showed relatively high cytotoxicity. Especially, compounds 5x and 5q exhibited the best cytotoxicity against KB and CNE2 cells with IC50 7.1 and 11.4 μM, respectively. Their inhibitory activities against KB and CNE2 cells were even higher than that of fluorouracil.

Synthesis and antiviral bioactivities of novel chiral bis-thiourea-type derivatives containing α-aminophosphonate moiety

Starting from 1-((1R,2R)-2-aminocyclohexyl)-3-substituted thioureas (3a-c) and substituted isothiocyanates (9a-d), chiral bis-thiourea derivatives containing α-aminophosphonate moiety 10a-l were prepared and completely characterized by elemental analysis, physical and spectral (IR, 1H NMR, 13C NMR, 31P NMR) data. The results of bioassay revealed that compounds 10a and 10e possessed appreciable curative bioactivities on cucumber mosaic virus (CMV) at 0.5 mg/mL in vivo (inhibitory rate = 60.3%, 64.8% respectively) and tobacco mosaic virus (TMV) at 0.5 mg/mL in vivo (inhibitory rate = 50.3%, 50.8% respectively), which were comparable to the values shown by standard reference (58.7%) and commercial product Ningnanmycin (56.3%), respectively. Chiral compound 10e displayed more potent antiviral activity (EC50 = 0.149 mg/mL) than Ningnanmycin (EC50 = 0.201mg/mL) against CMV.