1041361-26-5

Basic information

• Product Name: C₁₂H₁₃N₃O₂S₃
• Synonyms: C₁₂H₁₃N₃O₂S₃
• CAS NO: 1041361-26-5
• Molecular Weight: 327.452
• Mol File: 1041361-26-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₂H₁₃N₃O₂S₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₁₃N₃O₂S₃(1041361-26-5)
• EPA Substance Registry System: C₁₂H₁₃N₃O₂S₃(1041361-26-5)

Safety Data

• Hazardous Substances Data: 1041361-26-5(Hazardous Substances Data)

Upstream product

• 85103-35-1 5-(2-nitrophenyl)-1,3,4-thiadiazole-2-thiol 
• 693-07-2 2-Chloroethyl ethyl sulfide 

Relevant articles and documents

Synthesis and anti-Helicobacter pylori activity of 5-(nitroaryl)-1,3,4-thiadiazoles with certain sulfur containing alkyl side chain

A series of 5-(nitroaryl)-1,3,4-thiadiazoles bearing certain sulfur containing alkyl side chain similar to pendent residue in tinidazole molecule were synthesized and evaluated against Helicobacter pylori using disk diffusion method. The synthesized compounds were also evaluated for their antibacterial, antifungal and cytotoxic effects. Study of the structure-activity relationships of this series of compounds indicated that both the structure of the nitroaryl unit and the pendent group on 2-position of 1,3,4-thiadiazole ring dramatically impact the anti-H. pylori activity. While compound 7a containing 2-[2-(ethylsulfonyl)ethylthio]-side chain from nitrothiophene series was the most potent compound tested against clinical isolates of H. pylori, however, nitroimidazoles 6c and 7c were found to be more promising compounds because of their respectable anti-H. pylori activity besides less cytotoxic effects.