85103-35-1

Basic information

• Product Name: 5-(2-nitrophenyl)-1,3,4-thiadiazole-2-thiol
• Synonyms: 5-(2-nitrophenyl)-1,3,4-thiadiazole-2-thiol
• CAS NO: 85103-35-1
• Molecular Weight: 239.279
• Mol File: 85103-35-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 5-(2-nitrophenyl)-1,3,4-thiadiazole-2-thiol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-nitrophenyl)-1,3,4-thiadiazole-2-thiol(85103-35-1)
• EPA Substance Registry System: 5-(2-nitrophenyl)-1,3,4-thiadiazole-2-thiol(85103-35-1)

Safety Data

• Hazardous Substances Data: 85103-35-1(Hazardous Substances Data)

Upstream product

• 606-26-8 o-nitrobenzohydrazide 
• 113111-44-7 2-chloro-5-(2-nitrophenyl)-1,3,4-thiadiazole 
• 75-15-0 carbon disulfide 
• 832-79-1 5-(2-nitrophenyl)-1,3,4-thiadiazol-2-amine 
• 552-16-9 ortho-nitrobenzoic acid 

Downstream Products

• 1041361-44-7 C₁₂H₁₃N₃O₄S₃ 
• 1041361-26-5 C₁₂H₁₃N₃O₂S₃ 
• 51146-73-7 2-(methylthio)-5-(2-nitrophenyl)-1,3,4-thiadiazole 
• 1374831-10-3 C₁₅H₆F₃N₅O₂S₃ 
• 207236-13-3 2-ethylsulfanyl-5-(2-nitro-phenyl)-[1,3,4]thiadiazole 

Relevant articles and documents

AMIDE DERIVATIVES AS SIRTUIN MODULATORS

Provided herein are novel sirtuin-modulating compounds represented by Structural Formula (I) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.

Synthesis and anti-Helicobacter pylori activity of 5-(nitroaryl)-1,3,4-thiadiazoles with certain sulfur containing alkyl side chain

A series of 5-(nitroaryl)-1,3,4-thiadiazoles bearing certain sulfur containing alkyl side chain similar to pendent residue in tinidazole molecule were synthesized and evaluated against Helicobacter pylori using disk diffusion method. The synthesized compounds were also evaluated for their antibacterial, antifungal and cytotoxic effects. Study of the structure-activity relationships of this series of compounds indicated that both the structure of the nitroaryl unit and the pendent group on 2-position of 1,3,4-thiadiazole ring dramatically impact the anti-H. pylori activity. While compound 7a containing 2-[2-(ethylsulfonyl)ethylthio]-side chain from nitrothiophene series was the most potent compound tested against clinical isolates of H. pylori, however, nitroimidazoles 6c and 7c were found to be more promising compounds because of their respectable anti-H. pylori activity besides less cytotoxic effects.