104143-49-9Relevant articles and documents
REACTIONS SRN1 EN SERIE HETEROCYCLIQUE: IV: REACTIVITE DES SELS DU DIMETHYL-2,2 NITRO-5 DIOXANNE-1,3
Crozet, Michel P.,Archaimbault, Gaelle,Vanelle, Patrice,Nouguier, Robert
, p. 5133 - 5134 (1985)
2-Alkyl 2-nitro 1,3-propanediol, 2-alkylidene 1,3-propanediol and 2-dialkylidene 1,3-propanediol are prepared via SRN1 reactions with salts of 2,2-dimethyl 5-nitro 1,3-dioxane and acid-catalyzed cleavage of the resulting acetals.
Preparation and antiparasitic activity of new imidazoles bearing dioxane or hexahydropyrimidine moiety
Vanelle,Maldonado,Crozet,Senouki,Delmas,Gasquet,Timon-David
, p. 709 - 714 (2007/10/02)
5-Nitro-1,3-dioxane and 5-nitrohexahydropyrimidine salts are found to be suitable nucleophiles for S(RN)1 reactions. From C-alkylation products, base-promoted nitrous acid elimination and acid-catalyzed cleavage of the resulting acetals afford new compounds. Only the imidazole derivatives exhibit significant amoebicide and trichomonacide activities. Structure-activity relationships are discussed.