10433-52-0 Usage
Description
O-Benzyl-D-serine is a synthetic derivative of the naturally occurring amino acid D-serine, featuring a benzyl group attached to the hydroxyl group. It is a white to off-white powder with unique chemical properties that make it a versatile compound in various applications.
Uses
Used in Pharmaceutical Industry:
O-Benzyl-D-serine is used as an intermediate in the synthesis of pharmaceuticals for its ability to be efficiently converted from D-5-monosubstituted hydantoin by E.coli. This conversion process reveals three co-expressed genes encoding hydantoin racemase, D-hydantoinase, and N-carbamoyl-D-amino acid amidohydrolase, which are crucial for its production and potential therapeutic applications.
Used in Chemical Synthesis:
O-Benzyl-D-serine is used as a building block in the chemical synthesis of various organic compounds, taking advantage of its unique structure and reactivity. Its benzyl-protected serine moiety allows for selective reactions and the synthesis of complex molecules with potential applications in different industries.
Used in Research and Development:
In the field of research and development, O-Benzyl-D-serine serves as a valuable compound for studying enzyme mechanisms, exploring the scope of asymmetric synthesis, and developing new methodologies for the synthesis of biologically active molecules. Its unique properties make it an attractive candidate for probing enzyme selectivity and catalytic activity.
Used in Enzyme Inhibition Studies:
O-Benzyl-D-serine can be used in enzyme inhibition studies, particularly for enzymes that utilize D-serine as a substrate or inhibitor. Its modified structure allows researchers to investigate the binding preferences and specificity of enzymes, contributing to a better understanding of enzyme function and the development of enzyme-targeted therapies.
Overall, O-Benzyl-D-serine is a multifaceted compound with applications spanning across the pharmaceutical, chemical synthesis, research and development, and enzyme inhibition fields. Its unique properties and synthetic versatility make it a valuable asset in the development of new drugs, materials, and methodologies.
Check Digit Verification of cas no
The CAS Registry Mumber 10433-52-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,4,3 and 3 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 10433-52:
(7*1)+(6*0)+(5*4)+(4*3)+(3*3)+(2*5)+(1*2)=60
60 % 10 = 0
So 10433-52-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H13NO3/c11-9(10(12)13)7-14-6-8-4-2-1-3-5-8/h1-5,9H,6-7,11H2,(H,12,13)/t9-/m1/s1
10433-52-0Relevant articles and documents
Amine-boranes: Effective reducing agents for the deracemisation of DL-amino acids using L-amino acid oxidase from Proteus myxofaciens
Alexandre, Fran?ois-René,Pantaleone, David P.,Taylor, Paul P.,Fotheringham, Ian G.,Ager, David J.,Turner, Nicholas J.
, p. 707 - 710 (2002)
The deracemisation of DL-α-amino acids using L-amino acid oxidase from Proteus myxofaciens and amine-boranes as chemical reducing agents has been investigated. Amine-boranes were found to be of particular interest in terms of reactivity and chemoselectivity compared to sodium borohydride and cyanoborohydride. Starting from the racemate, a range of D-amino acids were obtained in yields of up to 90% and e.e. >99%.
Cinnamic acid derivative with aldose reductase inhibitory activity as well as preparation method and application thereof
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Paragraph 0076; 0082, (2017/09/01)
The invention discloses a cinnamic acid derivative with aldose reductase inhibitory activity, a preparation method thereof and an application of the cinnamic acid derivative in preparation of a medicine used for treating diabetic complications and diseases caused by oxidative stress. The structure of the compound is shown in a formula I. The preparation method comprises the following steps: firstly reacting substituted benzaldehyde with substituted acetic acid or acid anhydride thereof to obtain substituted cinnamic acid, then reacting with a diamine compound protected by N-tertiary butoxy acyl to obtain substituted cinnamoyl diamide protected by N-tertiary butoxy acyl; and carrying out tertiary butoxy acyl deprotection on the substituted cinnamoyl diamide protected by N-tertiary butoxy acyl, and then reacting with natural or non-natural N-acyl alpha-amino acid, so that the cinnamic acid derivative is obtained. The cinnamic acid derivative compound disclosed by the invention has excellent inhibitory activity on aldose reductase and excellent antioxidant activity and can be applied to preparation of a medicine used for treating the diabetic complications, especially diabetic retinopathy, senile dementia due to diabetes and nerve ending disturbance, as well as diseases caused by the oxidative stress.
Optical resolution of O-benzyl-N-formyl-(R)-(S)-serine
Pitre',Boveri,Buser
, p. 244 - 247 (2007/10/06)
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