47173-80-8 Usage
Description
N-Boc-O-Benzyl-D-serine is an amino acid derivative characterized by its white crystalline powder form. It plays a significant role in chemical synthesis and peptide chemistry due to its unique structural properties.
Uses
1. Chemical Synthesis and Peptide Chemistry:
N-Boc-O-Benzyl-D-serine is used as a building block in the chemical synthesis of various compounds and as a key component in peptide chemistry. Its application in this field is due to its ability to be incorporated into larger molecular structures, contributing to the development of novel pharmaceuticals and bioactive molecules.
2. Pharmaceutical Industry Cancer and Metabolic Disease Treatment:
N-Boc-O-Benzyl-D-serine is used as a precursor in the preparation of substituted naphthyl thiadiazolidinones. These compounds act as protein tyrosine phosphatase degraders, which have potential therapeutic applications in treating cancer and metabolic diseases. The degradation of these phosphatases can help regulate cellular signaling pathways, thereby providing a therapeutic approach to combat these diseases.
3. Research and Development:
In the field of research and development, N-Boc-O-Benzyl-D-serine is utilized for the synthesis of new molecules with potential biological activities. Its unique structure allows scientists to explore its properties and applications in creating innovative drugs and therapies for various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 47173-80-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,7,1,7 and 3 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 47173-80:
(7*4)+(6*7)+(5*1)+(4*7)+(3*3)+(2*8)+(1*0)=128
128 % 10 = 8
So 47173-80-8 is a valid CAS Registry Number.
InChI:InChI=1/C15H21NO5/c1-15(2,3)21-14(19)16-12(13(17)18)10-20-9-11-7-5-4-6-8-11/h4-8,12H,9-10H2,1-3H3,(H,16,19)(H,17,18)/p-1/t12-/m1/s1
47173-80-8Relevant articles and documents
Subtype-Specific Agonists for NMDA Receptor Glycine Binding Sites
Maolanon, Alex R.,Risgaard, Rune,Wang, Shuang-Yan,Snoep, Yoran,Papangelis, Athanasios,Yi, Feng,Holley, David,Barslund, Anne F.,Svenstrup, Niels,Hansen, Kasper B.,Clausen, Rasmus P.
, p. 1681 - 1687 (2017/08/21)
A series of analogues based on serine as lead structure were designed, and their agonist activities were evaluated at recombinant NMDA receptor subtypes (GluN1/2A-D) using two-electrode voltage-clamp (TEVC) electrophysiology. Pronounced variation in subunit-selectivity, potency, and agonist efficacy was observed in a manner that was dependent on the GluN2 subunit in the NMDA receptor. In particular, compounds 15a and 16a are potent GluN2C-specific superagonists at the GluN1 subunit with agonist efficacies of 398% and 308% compared to glycine. This study demonstrates that subunit-selectivity among glycine site NMDA receptor agonists can be achieved and suggests that glycine-site agonists can be developed as pharmacological tool compounds to study GluN2C-specific effects in NMDA receptor-mediated neurotransmission.
PYRROLOPYRROLONES ACTIVE AS KINASE INHIBITORS
-
Page/Page column 33, (2010/11/28)
Compounds represented by formula (I) wherein A, R1, R2, R3, and R4 are as defined in the specification, compositions thereof, and methods of use thereof.
Synthesis and biophysical studies of modified oligonucleotides containing acyclic amino alcohol nucleoside analogs
Ramasamy, Kanda S.,Stoisavljevic, Vesna
, p. 1845 - 1861 (2007/10/03)
Novel serine derivative of thymine was prepared and incorporated into oligonucleotides. These modified oligonucleotides were studied for their binding affinity with complementary DNA/RNA.
