104473-83-8 Usage
Description
Ebselen Oxide is a chemical compound derived from the oxidation of ebselen, which is known for its potent peroxynitrite scavenging properties. It lacks antioxidant activity, making it a suitable negative control for ebselen in various studies and applications.
Uses
Used in Pharmaceutical Research:
Ebselen Oxide is used as a negative control for ebselen in pharmaceutical research, allowing scientists to compare the effects of ebselen's antioxidant properties with those of Ebselen Oxide, which lacks such activity. This comparison aids in understanding the specific contributions of ebselen's antioxidant capabilities in various biological and medical contexts.
Used in Cerebral Infarction Treatment Research:
Although Ebselen Oxide itself does not possess antioxidant activity, it is used in research related to the treatment of cerebral infarctions. This application helps researchers to delineate the role of ebselen's antioxidant properties in the treatment process, as opposed to other potential mechanisms of action that may be at play.
Used in Antioxidant Activity Studies:
Ebselen Oxide serves as a valuable tool in studies focused on antioxidant activity. By comparing the effects of ebselen and Ebselen Oxide, researchers can better understand the specific contributions of antioxidant properties in various experimental setups, leading to more targeted and effective therapeutic approaches.
Check Digit Verification of cas no
The CAS Registry Mumber 104473-83-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,4,7 and 3 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 104473-83:
(8*1)+(7*0)+(6*4)+(5*4)+(4*7)+(3*3)+(2*8)+(1*3)=108
108 % 10 = 8
So 104473-83-8 is a valid CAS Registry Number.
104473-83-8Relevant articles and documents
The reaction of ebselen with peroxynitrite
Masumoto, Hiroshi,Sies, Helmut
, p. 262 - 267 (1996)
Ebselen, 2-phenyl-1,2-benzisoselenazol-3(2H)-one, rapidly reacts with peroxynitrite, the rate constant being of the order of 106 M-1 s-1; the reaction yields the selenoxide of the parent molecule, 2-phenyl-1,2- benzisosele
Ebselen as a peroxynitrite scavenger in vitro and ex vivo
Daiber, Andreas,Zou, Ming-Hui,Bachschmid, Markus,Ullrich, Volker
, p. 153 - 160 (2007/10/03)
We have previously shown that peroxynitrite (PN) selectively impaired prostacyclin (PGI2)-dependent vasorelaxation by tyrosine nitration of PGI2 synthase in an in situ model (Zou MH, Jendral M and Ullrich V, Br J Pharmacol 126: 1283-
MECHANISM OF THE CATALYTIC REDUCTION OF HYDROPEROXIDES BY EBSELEN : A SELENIUM - 77 NMR STUDY
Fisher, Hartmut,Dereu, Norbert
, p. 757 - 768 (2007/10/02)
Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one 1, a non-toxic selenium containing heterocyclic compound has been shown to display both anti-inflammatory activity in vivo and GSH-Px-like activity in vitro.Using (1)H and (77)Se NMr we investigated the mechanism of reduction of hydroperoxides by thiols in the presence of 1.A catalytic cycle depending on the formation of diselenides and selenylsulfides was found.The selenic acid oxidation level present in compound 1 is particularly stable because of the intermolecular cyclisation.This contracts with previously reported results concerning the oxidation of organoselenium compounds.
