104617-86-9

Basic information

• Product Name: (±)-PraMipexole
• Synonyms: 2-Amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole;Pramipexole Impurity 9
• CAS NO: 104617-86-9
• Molecular Formula: C₁₀H₁₇N₃S
• Molecular Weight: 211.32708
• Mol File: 104617-86-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 378°C at 760 mmHg
• Flash Point: 182.4°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 6.49E-06mmHg at 25°C
• Refractive Index: 1.582
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly, Heated), DMSO (Sparingly), Methanol (Slightly)
• CAS DataBase Reference: (±)-PraMipexole(CAS DataBase Reference)
• NIST Chemistry Reference: (±)-PraMipexole(104617-86-9)
• EPA Substance Registry System: (±)-PraMipexole(104617-86-9)

Safety Data

• Hazardous Substances Data: 104617-86-9(Hazardous Substances Data)

Usage

Description

(±)-PraMipexole, also known as Pramipexole, is a recemic analogue of (S)-Pramipexole (P700755), which is a dopamine-D2-receptor agonist. It is a pharmaceutical compound that has been synthesized to target and activate specific dopamine receptors in the brain, playing a crucial role in the treatment of certain neurological conditions.

Uses

Used in Pharmaceutical Industry:
(±)-PraMipexole is used as an antiparkinsonian agent for the treatment of Parkinson's disease. It helps alleviate the symptoms of the disease by mimicking the effects of dopamine, a neurotransmitter that is often deficient in Parkinson's patients. This leads to improved motor function and a reduction in the severity of symptoms such as tremors, rigidity, and bradykinesia.
Additionally, (±)-PraMipexole has been found to have potential applications in other areas of medicine, such as the treatment of restless legs syndrome and certain types of depression. However, these uses are still under investigation and may require further research to confirm their efficacy and safety.

InChI:InChI=1/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)

Upstream product

• 1044921-37-0 4-propanoamidocyclohexanone 
• 1156622-74-0 4-propionamidocyclohexanol 
• 6850-65-3 p-hydroxycyclohexylamine 
• 1026083-71-5 N-(2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-2,4,6-trimethyl-N-propylbenzenesulfonamide 
• 107-10-8 propylamine 
• 556-53-6 N-propylamine hydrochloride 
• 404892-20-2 2-amino-6-oxo-4,5,6,7-tetrahydrobenzothiazole hydrobromide 
• 113030-24-3 2-amino-6-oxo-4,5,6,7-tetrahydrobenzothiazole 
• 873536-19-7 C₉H₁₇NOS 
• 420-04-2 CYANAMID 
• 104618-25-9 N,N-4-oxocyclohexyl-n-propyl-amine 
• 375824-96-7 2-amino-6-(propionylamino)-4,5,6,7-tetrahydrobenzothiazole 
• 123-38-6 propionaldehyde 
• 106006-83-1 2,6-diamino-4,5,6,7-tetrahydro-benzthiazole 

Downstream Products

• 104632-28-2 (R)-(+)-pramipexole 
• 104632-26-0 pramipexole 
• 1563175-34-7 N6-(2-(4-(4′-methoxybiphenyl-4-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine 
• 1563175-35-8 N6-(2-(4-(3′-methoxybiphenyl-4-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine 
• 1563175-38-1 N6-(2-(4-(2′-methoxybiphenyl-4-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine 
• 1563175-39-2 N6-(4-(4-(3′-methoxy-[1,1′-biphenyl]-4-yl)piperazin-1-yl)butyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine 
• 1563175-06-3 N₆-(2-(4-(3-methoxybiphenyl-4-yl)piperazin-1-yl)ethyl)-N₆-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine 
• 1563175-14-3 (4-(2-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)ethyl)piperazin-1-yl)(biphenyl-4-yl)methanone 
• 1612146-72-1 (E)-4-(3-((2-amino-4,5,6,7-tetrahydrobenzo[d] thiazol-6-yl)(propyl)amino)prop-1-en-1-yl)-2-methoxyphenol 
• 1612146-61-8 4-(5-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)pentyl)-2-methoxyphenol 
• 1612146-64-1 4-(5-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)pentyl)benzene-1,2-diol 
• 1612146-68-5 (Z)-4-(5-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)pent-1-en-1-yl)-2-methoxyphenol 

Relevant articles and documents

A preparation method of pramipexole hydrochloride (by machine translation)

The invention discloses a method for preparation of pramipexole hydrochloride, comprises the following steps: to amino cyclohexyl [...] acyl chloride condensation for protecting amino group to obtain the propionyl cyclohexanol, then is obtained by catalyt

Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl] propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: Identification of highly potent and selective agonists for dopamine D3 receptor with potent in vivo activity

In the current report, we extend the SAR study on our hybrid structure 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen- 2-ol further to include heterocyclic bioisosteric analogues. Binding assays were carried out with HEK-29

METHOD FOR THE RESOLUTION OF 2-AMINO-6-PROPYLAMINO-4,5,6,7-TETRAHYDROBENZOTHIAZOL AND INTERMEDIATE COMPOUNDS

The invention relates to a novel method for the resolution of the racemic mixture of compound (R,S)-2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole, or the enrichment of same with in one of its enantiomers, and to intermediate compounds which can be used to perform said method.