104632-26-0Relevant articles and documents
Preparation method of high-purity pramipexole
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Paragraph 0059; 0064-0068; 0073-0076, (2021/04/07)
The invention relates to the technical field of pharmacy, and provides a preparation method of high-purity pramipexole. According to the invention, raceme 2, 6-diamino 4, 5, 6, 7-tetrahydrobenzothiazole is used as an initial raw material, and pramipexole is obtained through a three-step chemical reaction, so the introduction of uncontrollable factors of drug quality is reduced, and the requirements of drug application are better met; the market price of the initial raw materials is low, so that the preparation cost of pramipexole can be greatly reduced; the solvent used in the method is green, environmentally friendly, cheap, easy to obtain and suitable for industrial production, the HPLC purity of the obtained pramipexole can reach 99.86%, and the isomer purity can reach 99.89%.
Preparation method of pramipexole dihydrochloride
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Paragraph 0017-0025, (2020/05/09)
The invention relates to a preparation method of pramipexole dihydrochloride in the technical field of medicine preparation. The method includes adding (S)-2,6-diamino-4, 6-diamino-4,5,6,7-tetrahydrobenzothiazole adopted as an initial raw material I together with n-propyl p-toluenesulfonate into a toluene solvent; carrying out N-alkylation by the n-propyl p-toluenesulfonate under the action of analkali and a phase transfer catalyst to generate (S)-2-amino-6-propionamido-4,5,6,7-tetrahydrobenzothiazole (II); and dropwise adding hydrochloric acid for salifying the compound II in toluene to obtain the pramipexole dihydrochloride. According to the method, the n-propyl p-toluenesulfonate is selected as an alkylation reagent, an alkylation reaction of amino is completed in one step to obtain pramipexole, the hydrochloric acid is directly dropwise added into the pramipexole to form the salt without separation, the reaction steps are shortened, and the economic benefits of the product are improved.
Preparation method of pramipexole dihydrochloride and intermediate thereof
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Paragraph 0072; 0073; 0074; 0075; 0077; 0078; 0080; 0081, (2018/08/04)
The invention discloses a preparation method of pramipexole dihydrochloride and an intermediate thereof. The invention provides a preparation of pramipexole II. The preparation method of the pramipexole II comprises the following steps: performing condensation reaction and reduction reaction on a pramipexole intermediate III, propylamine and hydrogen in an organic solvent and under the existence of a chiral catalyst, and performing one-pot method to obtain the pramipexole II. According to the preparation method provided by the invention, the route step is short, chiral resolution is not neededand the total molar yield is high; furthermore, the prepared product has high purity, can reach to the standard of raw material medicines and is suitable for industrialized production. (The formula is shown in the description).