1048922-51-5

Basic information

• Product Name: 3-(4-Chloro-phenyl)-isoxazole-4-carboxylic acid
• Synonyms: 3-(4-Chloro-phenyl)-isoxazole-4-carboxylic acid
• CAS NO: 1048922-51-5
• Molecular Formula: C₁₀H₆ClNO₃
• Molecular Weight: 223.61254
• Mol File: 1048922-51-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-Chloro-phenyl)-isoxazole-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Chloro-phenyl)-isoxazole-4-carboxylic acid(1048922-51-5)
• EPA Substance Registry System: 3-(4-Chloro-phenyl)-isoxazole-4-carboxylic acid(1048922-51-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1048922-51-5(Hazardous Substances Data)

Usage

General Description

3-(4-chloro-phenyl)-isoxazole-4-carboxylic acid is a chemical compound with the molecular formula C10H6ClNO3. It is a derivative of isoxazole and contains a carboxylic acid functional group. 3-(4-chloro-phenyl)-isoxazole-4-carboxylic acid is commonly used in pharmaceutical research as a building block for the synthesis of various pharmaceutical compounds. It is also known to possess biological activity and has been studied for potential medicinal applications. Additionally, 3-(4-chloro-phenyl)-isoxazole-4-carboxylic acid may have potential industrial applications as a precursor in the synthesis of other organic compounds. Overall, this chemical compound has important implications in both pharmaceutical and industrial settings.

Upstream product

• 1173119-91-9 3-(4-chlorophenyl)-5-(trimethylsilanyl)isoxazole 
• 124-38-9 carbon dioxide 
• 31301-39-0 3-(4-chlorophenyl)-isoxazole 
• 471-25-0 Propiolic acid 
• 28123-63-9 4-chlorobenzohydroximoyl chloride 
• 104-88-1 4-chlorobenzaldehyde 
• 3848-36-0 4-chlorobenzaldoxime 
• 29363-98-2 3-(4-chloro-phenyl)-isoxazole-4-carboxylic acid ethyl ester 

Downstream Products

• 1159603-80-1 6-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester 
• 1159603-82-3 6-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-N-isopropyl-nicotinamide 
• 1198575-42-6 1-methyl-3,4-diphenyl-6-chloro-isoquinoline 
• 1380197-95-4 6-chloro-1,4-dimethyl-3-phenylisoquinoline 

Relevant articles and documents

Rhodium(iii)-catalysed decarboxylative C-H functionalization of isoxazoles with alkenes and sulfoxonium ylides

Decarboxylative C-H functionalization of isoxazoles with electron-deficient alkenes and sulfoxonium ylides at the C5 position was achieved in the presence of rhodium(iii) catalysts to give the corresponding alkenylation and acylmethylation products, respe

A field-based disparity analysis of new 1,2,5-oxadiazole derivatives endowed with antiproliferative activity

A series of 1,2,5-oxadiazoles were synthesized as new potential antiproliferative agents. The in vitro cytotoxic activity evaluation of title compounds through MTT assay revealed that some of them showed significant activity against the HCT-116 cancer cell line. The field-based disparity analysis provided indications about the electrostatic, hydrophobic, and shape features underlying the cytotoxicity, suggesting that increasing the negative electrostatic field on the heterocyclic core of the structure has positive effects on the activity. The structure–activity relationships (SAR) around a particular compound can be explained allowing for a structural rationale for the differences in activity. The SAR provided by this series of compounds can be exploited to carry out further lead optimization.

PROCESS FOR THE PREPARATION OF ISOXAZOLYL- METHOXY NICOTINIC ACIDS

The present invention relates to a process for the preparation of a compound of formula (I) wherein R1 and R2 are as defined herein, which is useful as an intermediate in the preparation of active pharmaceutical compounds.