104974-47-2 Usage
Description
(3R)-1-oxo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid is a carboxylic acid derivative of isoquinoline, characterized by a white crystalline powder form. It possesses a molecular formula of C11H11NO3 and features a tetrahydroisoquinoline ring, which is recognized for its biological activity. (3R)-1-oxo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid serves as a key intermediate in the synthesis of a range of pharmaceuticals, particularly antimalarial and antipsychotic drugs, due to its versatile chemical reactivity and potential therapeutic applications.
Uses
Used in Pharmaceutical Industry:
(3R)-1-oxo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid is utilized as a key intermediate in the synthesis of various pharmaceuticals, specifically for the development of antimalarial and antipsychotic drugs. Its tetrahydroisoquinoline ring and carboxylic acid group endow it with biological activity and chemical reactivity, making it a valuable building block for creating new drug compounds with therapeutic potential.
Check Digit Verification of cas no
The CAS Registry Mumber 104974-47-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,9,7 and 4 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 104974-47:
(8*1)+(7*0)+(6*4)+(5*9)+(4*7)+(3*4)+(2*4)+(1*7)=132
132 % 10 = 2
So 104974-47-2 is a valid CAS Registry Number.
104974-47-2Relevant articles and documents
Diastereoselective Addition of Lithiated N,N-Diethyl-o-Toluamide to Chiral Isopropylidene Glyceraldehyde Imines. Asymmetric Synthesis of 3-Substituted 3,4-Dihydro-1(2H)-isoquinolones
Clark, Robin D.,Jahangir,Souchet, Michel,Kern, John R.
, p. 930 - 931 (1989)
The lithio derivative of N,N-diethyl-o-toluamide adds regiospecifically to (R)- and (S)-glyceraldehyde acetonide p-methoxybenzyl imines to afford the Cram-chelation controlled products (3S,1'R)-(3) and (3R,1')-(3), respectively.
