124455-22-7Relevant articles and documents
Chelation control in the addition of homophthalic anhydride to α-alkoxy imines. Pancratistatin model studies
Clark, Robin D.,Souchet, Michel
, p. 193 - 196 (2007/10/02)
Diastereoselectivity in the addition of homophthalic anhydride to the α-alkoxy imine (S)-5 can be increased dramatically (to> 90%) with addition of Lewis acids. This methodology has been applied to the synthesis of a model compound (12) which contains four asymmetric centers with the same relative stereochemistry as pancratistatin (1).