105072-35-3

Basic information

• Product Name: Piperidine, 1-[(4-nitrophenyl)acetyl]-
• CAS NO: 105072-35-3
• Molecular Formula: C13H16N2O3
• Molecular Weight: 248.282
• Mol File: 105072-35-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Piperidine, 1-[(4-nitrophenyl)acetyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine, 1-[(4-nitrophenyl)acetyl]-(105072-35-3)
• EPA Substance Registry System: Piperidine, 1-[(4-nitrophenyl)acetyl]-(105072-35-3)

Safety Data

• Hazardous Substances Data: 105072-35-3(Hazardous Substances Data)

Upstream product

• 104-03-0 4-nitrobenzeneacetic acid 
• 110-89-4 piperidine 
• 2945-08-6 methyl (4-nitrophenyl)acetate 
• 2981-10-4 1-(cyclohex-1-en-1-yl)piperidine 
• 146736-31-4 3-Chloro-3-(4-nitro-phenyl)-2-oxo-propionic acid methyl ester 
• 352564-38-6 C₁₃H₁₆N₂O₂S 
• 555-16-8 4-nitrobenzaldehdye 
• 51738-10-4 2,2-dibromo-1-(4-nitrophenyl)ethene 
• 937-31-5 (4-Nitrophenyl)acetylene 

Downstream Products

• 69576-95-0 4-nitrophenyl-1-piperidinostyrene 
• 5339-15-1 1-[2-(4-nitro-phenyl)-ethyl]-piperidine 
• 168897-21-0 4-(2-piperidin-1-yl-ethyl)-phenylamine 

Relevant articles and documents

An Efficient One–pot Procedure for the Direct Preparation of 4,5-Dihydroisoxazoles from Amides

A Mo(CO)6 (molybdenumhexacarbonyl) catalyzed reductive functionalization of amides to afford 5-amino substituted 4,5-dihydroisoxazoles is presented. The reduction of amides generates reactive enamines, which upon the addition of hydroximinoyl chlorides and base undergoes a 1,3-dipolar cycloaddition reaction that gives access to the desired heterocyclic compounds. The transformation of amides is highly chemoselective and tolerates functional groups such as nitro, nitriles, esters, and ketones. Furthermore, a versatile scope of 4,5-dihydroisoxazoles derived from a variety of hydroximinoyl chlorides and amides is demonstrated. (Figure presented.).

Visible-light-mediated eosin y catalyzed aerobic desulfurization of thioamides into amides

A novel method for the metal-free efficient synthesis of amides from thioamides using visible light and in an air atmosphere in the presence of eosin Y as an organophotoredox catalyst is reported. The protocol involves aerobic desulfurization-oxygenation of thioamides into amides in good to excellent yields at r.t. in a one-pot operation under mild conditions with the formation of nontoxic elemental sulfur as the only by-product. On the basis of several relevant experiments performed, it has been shown that the present photooxidation does not involve a singlet oxygen and accordingly a plausible organocatalytic photoredox mechanism is proposed.

Synthesis and biological evaluation of new 4β-anilino-4′-O- demethyl-4-desoxypodophyllotoxin derivatives as potential antitumor agents

A series of new 4β-anilino-4′-O-demethyl-4-desoxypodophyllotoxin derivatives were prepared and evaluated for their cytotoxicities against four human cancer cell lines including KB, KB/VCR, A549 and 95D. Most compounds showed better growth-inhibition activities against tested cell lines than that of etoposide (VP-16). Preliminary structure-activity relationships (SARs) were concluded and it indicated that the side chains substituted at 4β position of podophyllotoxin significantly influenced the cytotoxic activity, especially for the drug resistance profile. In vivo studies of compound 26c on highly metastatic human lung cancer xenograft in nude mice showed that it can significantly inhibit tumor growth with administrating by oral route.