168897-21-0

Basic information

• Product Name: 4-(2-PIPERIDIN-1-YL-ETHYL)-ANILINE
• Synonyms: 4-(2-PIPERIDIN-1-YL-ETHYL)-ANILINE;4-(2-Piperidin-1-yl-ethyl)-phenylamine;4-(2-Piperidinoethyl)aniline
• CAS NO: 168897-21-0
• Molecular Formula: C₁₃H₂₀N₂
• Molecular Weight: 204.31
• Mol File: 168897-21-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 332.135°C at 760 mmHg
• Flash Point: 139.597°C
• Appearance: /
• Density: 1.031g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.567
• CAS DataBase Reference: 4-(2-PIPERIDIN-1-YL-ETHYL)-ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-PIPERIDIN-1-YL-ETHYL)-ANILINE(168897-21-0)
• EPA Substance Registry System: 4-(2-PIPERIDIN-1-YL-ETHYL)-ANILINE(168897-21-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 168897-21-0(Hazardous Substances Data)

Usage

General Description

4-(2-piperidin-1-yl-ethyl)-aniline is a chemical compound that has a molecular formula of C14H22N2. It is a substituted aniline with a piperidine functional group attached to the benzene ring. 4-(2-PIPERIDIN-1-YL-ETHYL)-ANILINE is commonly used in the synthesis of pharmaceuticals, such as antihistamines and antipsychotic medications. It is also used as an intermediate in the production of various organic compounds and can be employed as a building block for the creation of other chemicals. 4-(2-piperidin-1-yl-ethyl)-aniline may also have applications in research and development, particularly in the field of drug discovery and chemical synthesis.

InChI:InChI=1/C13H20N2/c14-13-6-4-12(5-7-13)8-11-15-9-2-1-3-10-15/h4-7H,1-3,8-11,14H2

Upstream product

• 103-63-9 1-phenyl-2-bromoethane 
• 105072-35-3 2-(4-nitrophenyl)-1-(piperidin-1-yl)ethan-1-one 
• 555-16-8 4-nitrobenzaldehdye 
• 51738-10-4 2,2-dibromo-1-(4-nitrophenyl)ethene 
• 110-89-4 piperidine 
• 5339-26-4 (4-nitrophenyl)ethyl bromide 
• 5339-15-1 1-[2-(4-nitro-phenyl)-ethyl]-piperidine 
• 3544-25-0 p-aminophenylacetonitrile 
• 64-17-5 ethanol 

Downstream Products

• 1567327-20-1 5,6-dimethoxy-2-(4-(2-(piperidin-1-yl)ethyl)phenyl)benzo[d][1,2]selenazol-3(2H)-one 
• 229003-44-5 7-phenyl-N-[4-(2-piperidinoethyl)phenyl]-3,4-dihydro-naphthalene-2-carboxamide 
• 229004-34-6 N-(4-(2-piperidinoethyl)phenyl)-7-(4-methylphenyl)-2,3-dihydro-1-benzoxepine-4-carboxamide 
• 266678-25-5 4-[4-(2-piperidin-1-yl-ethyl)-phenylcarbamoyl]-butyric acid 2-{ethyl-[4-(4-nitro-phenylazo)-phenyl]-amino}-ethyl ester 
• 82966-19-6 1-<(4-Hydroxy-phenyl)-ethyl>-piperidin 

Relevant articles and documents

Synthesis and biological evaluation of a new series of ebselen derivatives as glutathione peroxidase (GPx) mimics and cholinesterase inhibitors against Alzheimer's disease

A series of ebselen derivatives were designed, synthesised and evaluated as inhibitors of cholinesterases (ChEs) and glutathione peroxidase (GPx) mimics. Most of the compounds were found to be potent against AChEs and BuChE, compounds 5e and 5i, proved to be the most potent against AChE with IC50 values of 0.76 and 0.46 μM, respectively. Among these hybrids, most of the compounds were found to be good GPx mimics compare with ebselen. The selected compounds 5e and 5i were also used to determine the catalytic parameters and in vitro hydrogen peroxide scavenging activity. The results indicate that compounds 5e and 5i may be excellent multifunctional agents for the treatment of AD.

THIA-TETRAAZAACENAPHTHYLENE KINASE INHIBITORS

The present invention is directed to novel thia-tetraazaacenaphthylene compounds of Formula (I): and pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of ATP-protein kinase interactions.

3-(Arylamino)methylene-1, 3-dihydro-2H-indol-2-ones as kinase inhibitors

The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.