10516-60-6

Basic information

• Product Name: ethyl 2-([1,1'-biphenyl]-4-yl)propanoate
• CAS NO: 10516-60-6
• Molecular Weight: 254.329
• Mol File: 10516-60-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: ethyl 2-([1,1'-biphenyl]-4-yl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-([1,1'-biphenyl]-4-yl)propanoate(10516-60-6)
• EPA Substance Registry System: ethyl 2-([1,1'-biphenyl]-4-yl)propanoate(10516-60-6)

Safety Data

• Hazardous Substances Data: 10516-60-6(Hazardous Substances Data)

Upstream product

• 5459-35-8 2-bromo-acrylic acid ethyl ester 
• 5122-94-1 4-biphenylboronic acid 
• 50712-64-6 ethyl 2-(4-nitrophenyl)propionate 
• 98-80-6 phenylboronic acid 
• 14062-23-8 4-biphenylylacetic acid ethyl ester 
• 74-88-4 methyl iodide 
• 37940-57-1 1-biphenyl-4-yl-propan-1-one 
• 122-51-0 orthoformic acid triethyl ester 
• 5728-52-9 (4-biphenylyl)acetic acid 
• 609-08-5 Diethyl methylmalonate 
• 92-66-0 4-bromo-1,1'-biphenyl 
• 103362-70-5 potassium ethyl methylmalonate 

Downstream Products

• 6341-72-6 2-(4-biphenylyl)propanoic acid 

Relevant articles and documents

Pd-catalyzed decarboxylative cross-couplings of potassium malonate monoesters with aryl halides

An efficient catalytic protocol for Pd-catalyzed decarboxylative cross-coupling of potassium malonate monoesters and derivatives with aryl bromides and chlorides are described. Because of its broad applicability, this new catalytic system provides an alternative method for the preparation of diverse aryl acetic acids and derivatives.

The Suzuki-Miyaura Coupling of Nitroarenes

Synthesis of biaryls via the Suzuki-Miyaura coupling (SMC) reaction using nitroarenes as an electrophilic coupling partners is described. Mechanistic studies have revealed that the catalytic cycle of this reaction is initiated by the cleavage of the aryl-nitro (Ar-NO2) bond by palladium, which represents an unprecedented elemental reaction.

Oxidative Rearrangement of Aryl Ethyl Ketones to Alkyl 2-Arylpropanoates by Lead(IV) Acetate

Treatment of the propiophenones p-R'C6H4COCH2Me (1; R' = H, Me, Bui, Ph, Br) with lead(IV) acetate in trialkyl orthoformate in the presence of acid catalyst is found to give alkyl esters of 2-arylpropanoic acids (2) in good to excellent yields via 1,2-aryl migration in (1).Hydrolysis of (2) leads to the corresponding acids, some of which are important pharmaceutical compounds.The rate of aryl migration increases when the substituent R' is an electron-releasing group such as methyl, isobutyl, or phenyl.The rate of rearrangement of the dimethyl acetals of (1); R' = H, Bui, Ph) is nearly the same as that of (1).Such rearrangement hardly occurs in the absence of acid catalyst.A reaction pathway involving the formation of a monoalkoxylead(IV) compound, and its decomposition accompanied with aryl migration is discussed.