6341-72-6 Usage
Description
Alpha-Methyl-4-biphenylacetic acid, also known as a metabolite of Isopropylbiphenyl, is a compound that has been identified for its selective inhibition of COX-2, an enzyme involved in the production of prostaglandins. This property makes it a potential candidate for pharmaceutical applications, particularly in the area of pain relief and inflammation management. Additionally, it is recognized as an impurity in Flurbiprofen, a nonsteroidal anti-inflammatory drug (NSAID).
Uses
Used in Pharmaceutical Industry:
Alpha-Methyl-4-biphenylacetic acid is used as an active pharmaceutical ingredient (API) for its COX-2 selective inhibition properties, which can be beneficial in the development of anti-inflammatory and pain relief medications.
Used in Quality Control and Drug Purity Assessment:
As an identified impurity in Flurbiprofen, alpha-Methyl-4-biphenylacetic acid plays a role in the quality control and drug purity assessment processes within the pharmaceutical industry. Its presence is monitored to ensure the safety and efficacy of the final drug product.
Used in Research and Development:
Due to its COX-2 selective inhibition, alpha-Methyl-4-biphenylacetic acid is also utilized in research and development for the discovery of new drugs and therapies targeting inflammation and pain. Its study can contribute to a better understanding of the underlying mechanisms of these conditions and potentially lead to the development of more effective treatments.
Synthesis Reference(s)
Synthesis, p. 456, 1982 DOI: 10.1055/s-1982-29832
Check Digit Verification of cas no
The CAS Registry Mumber 6341-72-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,3,4 and 1 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 6341-72:
(6*6)+(5*3)+(4*4)+(3*1)+(2*7)+(1*2)=86
86 % 10 = 6
So 6341-72-6 is a valid CAS Registry Number.
InChI:InChI=1/C15H14O2/c1-11(15(16)17)12-7-9-14(10-8-12)13-5-3-2-4-6-13/h2-11H,1H3,(H,16,17)
6341-72-6Relevant articles and documents
Palladium-catalyzed hydrodefluorination of fluoroarenes
Brodney, Michael A.,Gair, Joseph J.,Giroux, Simon,Grey, Ronald L.
, p. 131 - 146 (2021/06/18)
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Site-Selective, Remote sp3 C?H Carboxylation Enabled by the Merger of Photoredox and Nickel Catalysis
Sahoo, Basudev,Bellotti, Peter,Juliá-Hernández, Francisco,Meng, Qing-Yuan,Crespi, Stefano,K?nig, Burkhard,Martin, Ruben
supporting information, p. 9001 - 9005 (2019/06/24)
A photoinduced carboxylation of alkyl halides with CO2 at remote sp3 C?H sites enabled by the merger of photoredox and Ni catalysis is described. This protocol features a predictable reactivity and site selectivity that can be modulated by the ligand backbone. Preliminary studies reinforce a rationale based on a dynamic displacement of the catalyst throughout the alkyl side chain.
Visible-Light-Driven External-Reductant-Free Cross-Electrophile Couplings of Tetraalkyl Ammonium Salts
Liao, Li-Li,Cao, Guang-Mei,Ye, Jian-Heng,Sun, Guo-Quan,Zhou, Wen-Jun,Gui, Yong-Yuan,Yan, Si-Shun,Shen, Guo,Yu, Da-Gang
, p. 17338 - 17342 (2019/01/04)
Cross-electrophile couplings between two electrophiles are powerful and economic methods to generate C-C bonds in the presence of stoichiometric external reductants. Herein, we report a novel strategy to realize the first external-reductant-free cross-electrophile coupling via visible-light photoredox catalysis. A variety of tetraalkyl ammonium salts, bearing primary, secondary, and tertiary C-N bonds, undergo selective couplings with aldehydes/ketone and CO2. Notably, the in situ generated byproduct, trimethylamine, is efficiently utilized as the electron donor. Moreover, this protocol exhibits mild reaction conditions, low catalyst loading, broad substrate scope, good functional group tolerance, and facile scalability. Mechanistic studies indicate that benzyl radicals and anions might be generated as the key intermediates via photocatalysis, providing a new direction for cross-electrophile couplings.