6524-81-8

Basic information

• Product Name: ethyl 2-([1,1'-biphenyl]-4-yl)propanoate
• CAS NO: 6524-81-8
• Molecular Weight: 254.329
• Mol File: 6524-81-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: ethyl 2-([1,1'-biphenyl]-4-yl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-([1,1'-biphenyl]-4-yl)propanoate(6524-81-8)
• EPA Substance Registry System: ethyl 2-([1,1'-biphenyl]-4-yl)propanoate(6524-81-8)

Safety Data

• Hazardous Substances Data: 6524-81-8(Hazardous Substances Data)

Upstream product

• 14062-23-8 4-biphenylylacetic acid ethyl ester 
• 74-88-4 methyl iodide 
• 92-66-0 4-bromo-1,1'-biphenyl 
• 103362-70-5 potassium ethyl methylmalonate 
• 609-08-5 Diethyl methylmalonate 
• 5459-35-8 2-bromo-acrylic acid ethyl ester 
• 5122-94-1 4-biphenylboronic acid 
• 37940-57-1 1-biphenyl-4-yl-propan-1-one 
• 122-51-0 orthoformic acid triethyl ester 
• 50712-64-6 ethyl 2-(4-nitrophenyl)propionate 
• 98-80-6 phenylboronic acid 
• 5728-52-9 (4-biphenylyl)acetic acid 

Downstream Products

• 6341-72-6 2-(4-biphenylyl)propanoic acid 

Relevant articles and documents

Synthesis method of carbonyl alpha-position monomethyl substituted compound

The invention discloses a synthesis method of a carbonyl alpha-position monomethyl substituted compound, thesynthesis method comprises the following steps: taking substituted phenylboronic acid and ethyl 2-bromoacrylate as raw materials, taking THF and water as solvents, reacting K2CO3 and a catalyst Pd (OAc) 2 under the protection of nitrogen, purifying to obtain an intermediate product, dissolving the intermediate product in a methanol solvent, performing catalytic hydrogenation, reacting at room temperature, filtering, and spin-drying the solvent to obtain the carbonyl alpha-position monomethyl substituted compound. According to the synthesis method of the carbonyl alpha-position monomethyl substituted compound, the target compound can be conveniently obtained, the toxicity of reagents participating in the reaction is small, and the reaction conditions are mild. Post-treatment is simple and safe, the product quality is good, and the method is suitable for large-scale production.

Pd-catalyzed decarboxylative cross-couplings of potassium malonate monoesters with aryl halides

An efficient catalytic protocol for Pd-catalyzed decarboxylative cross-coupling of potassium malonate monoesters and derivatives with aryl bromides and chlorides are described. Because of its broad applicability, this new catalytic system provides an alternative method for the preparation of diverse aryl acetic acids and derivatives.

Oxidative Rearrangement of Aryl Ethyl Ketones to Alkyl 2-Arylpropanoates by Lead(IV) Acetate

Treatment of the propiophenones p-R'C6H4COCH2Me (1; R' = H, Me, Bui, Ph, Br) with lead(IV) acetate in trialkyl orthoformate in the presence of acid catalyst is found to give alkyl esters of 2-arylpropanoic acids (2) in good to excellent yields via 1,2-aryl migration in (1).Hydrolysis of (2) leads to the corresponding acids, some of which are important pharmaceutical compounds.The rate of aryl migration increases when the substituent R' is an electron-releasing group such as methyl, isobutyl, or phenyl.The rate of rearrangement of the dimethyl acetals of (1); R' = H, Bui, Ph) is nearly the same as that of (1).Such rearrangement hardly occurs in the absence of acid catalyst.A reaction pathway involving the formation of a monoalkoxylead(IV) compound, and its decomposition accompanied with aryl migration is discussed.