105367-81-5

Basic information

• Product Name: (+)-lariciresinol
• CAS NO: 105367-81-5
• Molecular Weight: 360.407
• Mol File: 105367-81-5.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: (+)-lariciresinol(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-lariciresinol(105367-81-5)
• EPA Substance Registry System: (+)-lariciresinol(105367-81-5)

Safety Data

• Hazardous Substances Data: 105367-81-5(Hazardous Substances Data)

Usage

General Description

(+)-Lariciresinol is a lignan compound found in a variety of plant sources, including flaxseeds, sesame seeds, and various fruits and vegetables. It has been studied for its potential health benefits, including antioxidant, anti-inflammatory, and anti-cancer properties. Research has shown that (+)-lariciresinol may have protective effects against cardiovascular disease, diabetes, and age-related diseases. It is also being explored for its potential use in skincare and cosmetic products due to its antioxidant and anti-aging properties. Additionally, (+)-lariciresinol has shown promise in improving cognitive function and reducing symptoms of anxiety and depression. Overall, this compound has demonstrated numerous potential health benefits and is the subject of ongoing research for its various therapeutic applications.

Upstream product

• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 92831-74-8 4-<<4-(benzyloxy)-3-methoxyphenyl>methyl>dihydro-2(3H)-furanone 
• 112747-98-5 7S,8R,8'R-(-)-Lariciresinol-4,4'-bis-O-β-D-glucopyranoside 
• 112747-98-5 clemastanin B 
• 143663-00-7 (+)-lariciresinol 4'-O-β-D-glucopyranoside 

Downstream Products

• 121-34-6 3-methoxy-4-hydroxybenzoic acid 
• 121-33-5 vanillin 
• 5502-30-7 7-acetoxy-1-(4-acetoxy-3-methoxy-phenyl)-2,3-bis-acetoxymethyl-6-methoxy-1,2,3,4-tetrahydro-naphthalene 
• 95810-25-6 (4-(3,4-dimethoxybenzyl)-2-(3,4-dimethoxyphenyl)tetrahydrofuran-3-yl)methanol 
• 4097-63-6 2-methoxy-4,6-dinitrophenol 
• 4676-53-3 optically inactive 6,7-dimethoxy-2,3-bis-hydroxymethyl-1-(3,4-dimethoxy-phenyl)-tetralin 
• 5234-71-9 isolariciresinol 
• 63015-84-9 4-(4-Hydroxy-3-methoxy-phenyl)-7-methoxy-1,3,3a,4,9,9a-hexahydro-naphtho[2,3-c]furan-6-ol 
• 90-05-1 2-methoxy-phenol 
• 91-57-6 2-Methylnaphthalene 
• 1173194-39-2 3,3',4,4'-pentahydroxy-7,9'-epoxylignan 
• 5234-71-9 (6R,7R,8S)-isolariciresinol 
• 29388-33-8 (3R,4R)-3,4-bis(4-hydroxy-3-methoxybenzyl)-4-butanolide 
• 91-20-3 naphthalene 

Relevant articles and documents

Furanoid and furofuranoid lignans from Daphne oleoides

Furofuranoid lignan (1) and (2) and furanoid lignan (3) have been isolated from Daphne oleoides and their structures elucidated through chemical and spectroscopic studies as 2-(3′-methoxy-4′-O-α-D-galactopyranosylphenyl)-6-(3″- methoxy-4″-hydroxyphenyl)-3,7-dioxabicyclo[3.3.0]octane (1), 2-(3′,5′-dimethoxy-4′-O-α-D-galactopyranosylphenyl)-6- (3″-methoxy-4″-hydroxyphenyl)-3,7-dioxabicyclo[3.3.0]octane (2), and 4,9′-dihydroxy-3,3′-dimethoxy-4′-O-ss-D-glucopyranosyl- 7′,9-epoxylignan (3). Two known lignans (4) and (5) have also been reported for the first time from this species.

Enantioselective lignan synthesis by cell-free extracts of Forsythia koreana

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Pinoresinol-lariciresinol reductase: Substrate versatility, enantiospecificity, and kinetic properties

Two western red cedar pinoresinol-lariciresinol reductase (PLR) homologues were studied to determine their enantioselective, substrate versatility, and kinetic properties. PLRs are downstream of dirigent protein engendered, coniferyl alcohol derived, stereoselective coupling to afford entry into the 8- and 8′-linked furofuran lignan, pinoresinol. Our investigations showed that each PLR homolog can enantiospecifically metabolize different furofuran lignans with modified aromatic ring substituents, but where phenolic groups at both C4/C4′ are essential for catalysis. These results are consistent with quinone methide intermediate formation in the PLR active site. Site-directed mutagenesis and kinetic measurements provided additional insight into factors affecting enantioselectivity and kinetic properties. From these data, PLRs can be envisaged to allow for the biotechnological potential of generation of various lignan skeleta, that could be differentially “decorated” on their aromatic ring substituents, via the action of upstream dirigent proteins.