105580-45-8 Usage
General Description
4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid monomethyl ester is a chemical compound that belongs to the dihydropyridine class of calcium channel blockers. It is used as a medication to treat high blood pressure and chest pain caused by angina. 4-(2,3-DICHLORO-PHENYL)-2,6-DIMETHYL-1,4-DIHYDRO-PYRIDINE-3,5-DICARBOXYLIC ACID MONOMETHYL ESTER works by relaxing blood vessels and improving blood flow, which helps to lower blood pressure and reduce the workload on the heart. It is commonly prescribed under the brand name Adalat, and is available in both immediate-release and extended-release formulations for oral administration. This chemical is an important therapeutic agent in the management of cardiovascular diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 105580-45-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,5,8 and 0 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 105580-45:
(8*1)+(7*0)+(6*5)+(5*5)+(4*8)+(3*0)+(2*4)+(1*5)=108
108 % 10 = 8
So 105580-45-8 is a valid CAS Registry Number.
105580-45-8Relevant articles and documents
Acyloxymethyl as an activating group in lipase-catalyzed enantioselective hydrolysis. A versatile approach to chiral 4-aryl-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylates
Ebiike,Terao,Achiwa
, p. 5805 - 5808 (2007/10/02)
The first practical syntheses of chiral 4-aryl-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylates, which are attractive compounds as new calcium antagonists, were realized by lipase-catalyzed enantioselective hydrolysis of the acyloxymethyl esters. The monoesters obtained were revealed to have high optical purity and demonstrated to be useful chiral synthons.
