138279-25-1

Basic information

• Product Name: 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-, (2,2-dimethyl-1-oxopropoxy)methyl methyl ester
• CAS NO: 138279-25-1
• Molecular Formula: C24H29Cl2NO7
• Molecular Weight: 514.403
• Mol File: 138279-25-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-, (2,2-dimethyl-1-oxopropoxy)methyl methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-, (2,2-dimethyl-1-oxopropoxy)methyl methyl ester(138279-25-1)
• EPA Substance Registry System: 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-, (2,2-dimethyl-1-oxopropoxy)methyl methyl ester(138279-25-1)

Safety Data

• Hazardous Substances Data: 138279-25-1(Hazardous Substances Data)

Upstream product

• 138299-11-3 bis(pivaloyloxymethyl) 4-(2,3-dichlorophenyl)-1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-3,5-pyridinedicarboxylate 
• 141600-77-3 4-(2,3-Dichloro-phenyl)-1-methoxymethyl-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 
• 18997-19-8 Chloromethyl pivalate 
• 186581-53-3 diazomethane 
• 138279-19-3 4-(2,3-Dichloro-phenyl)-1-methoxymethyl-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid mono-(2,2-dimethyl-propionyloxymethyl) ester 

Downstream Products

• 105580-45-8 4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid monomethyl ester 
• 138279-28-4 (+)-methyl pivaloyloxymethyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 

Relevant articles and documents

Acyloxymethyl as an activating group in lipase-catalyzed enantioselective hydrolysis. A versatile approach to chiral 4-aryl-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylates

The first practical syntheses of chiral 4-aryl-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylates, which are attractive compounds as new calcium antagonists, were realized by lipase-catalyzed enantioselective hydrolysis of the acyloxymethyl esters. The monoesters obtained were revealed to have high optical purity and demonstrated to be useful chiral synthons.