105707-01-5

Basic information

• Product Name: diacetyllysine S-α-phenylethylamide
• CAS NO: 105707-01-5
• Molecular Weight: 333.431
• Mol File: 105707-01-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: diacetyllysine S-α-phenylethylamide(CAS DataBase Reference)
• NIST Chemistry Reference: diacetyllysine S-α-phenylethylamide(105707-01-5)
• EPA Substance Registry System: diacetyllysine S-α-phenylethylamide(105707-01-5)

Safety Data

• Hazardous Substances Data: 105707-01-5(Hazardous Substances Data)

Upstream product

• 830-03-5 4-nitrophenol acetate 
• 108-24-7 acetic anhydride 
• 111491-63-5 S-α-phenylethylamide of 5-cyano-2-hydroxyiminovaleric acid 
• 3073-58-3 N,N'-pentane-1,5-diyldiacetamide 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 105707-00-4 N-[4-(2-Methyl-5-oxo-4,5-dihydro-oxazol-4-yl)-butyl]-acetamide 
• 35436-74-9 N^α,N^ε-diacetyl-L-lysine 

Relevant articles and documents

ASYMMETRIC SYNTHESIS OF LYSINE DERIVATIVES BY DIASTEREOSELECTIVE HYDROGENATION

The hydrogenation of the S-α-phenylethylamide of 5-cyano-2-hydroxyiminovaleric acid at Raney nickel catalyst at atmospheric pressure in dioxane or tert-butyl alcohol with the addition of acetic anhydride leads to the formation of the corresponding amide of diacetyllysine having the preferred R configuration with a 10-14 percent excess of the R,S-diastereomer.Hydrogenation of the same substrate in solvents containing α-phenylethylamine takes place at increased pressure and gives the S-phenylethylamide of R-lysine with a 3-12percent excess of the diastereomer, depending on the employed solvent.

ASYMMETRICAL SYNTHESIS OF LYSINE DERIVATIVES

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