111491-63-5

Basic information

• Product Name: S-α-phenylethylamide of 5-cyano-2-hydroxyiminovaleric acid
• CAS NO: 111491-63-5
• Molecular Weight: 259.308
• Mol File: 111491-63-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: S-α-phenylethylamide of 5-cyano-2-hydroxyiminovaleric acid(CAS DataBase Reference)
• NIST Chemistry Reference: S-α-phenylethylamide of 5-cyano-2-hydroxyiminovaleric acid(111491-63-5)
• EPA Substance Registry System: S-α-phenylethylamide of 5-cyano-2-hydroxyiminovaleric acid(111491-63-5)

Safety Data

• Hazardous Substances Data: 111491-63-5(Hazardous Substances Data)

Upstream product

• 6976-79-0 ethyl 5-cyano-2-oximinovalerate 
• 2627-86-3 (S)-1-phenyl-ethylamine 

Downstream Products

• 3073-58-3 N,N'-pentane-1,5-diyldiacetamide 
• 111491-64-6 (Z)-3,5-Dimethyl-8,9,10,10a-tetrahydro-7H-imidazo[1,5-c][1,3]diazocin-1-one 
• 105707-01-5 diacetyllysine S-α-phenylethylamide 
• 111491-68-0 diacetyllysine S-α-phenylethylamide 
• 111491-67-9 (R,S)-lysine α-phenylethylamide 
• 111524-04-0 (S,S)-lysine α-phenylethylamide 

Relevant articles and documents

ASYMMETRIC SYNTHESIS OF LYSINE DERIVATIVES BY DIASTEREOSELECTIVE HYDROGENATION

The hydrogenation of the S-α-phenylethylamide of 5-cyano-2-hydroxyiminovaleric acid at Raney nickel catalyst at atmospheric pressure in dioxane or tert-butyl alcohol with the addition of acetic anhydride leads to the formation of the corresponding amide of diacetyllysine having the preferred R configuration with a 10-14 percent excess of the R,S-diastereomer.Hydrogenation of the same substrate in solvents containing α-phenylethylamine takes place at increased pressure and gives the S-phenylethylamide of R-lysine with a 3-12percent excess of the diastereomer, depending on the employed solvent.