1057256-43-5Relevant articles and documents
3,4-Disubstituted indole acylsulfonamides: A novel series of potent and selective human EP3 receptor antagonists
Zhou, Nian,Zeller, Wayne,Krohn, Michael,Anderson, Herb,Zhang, Jun,Onua, Emmanuel,Kiselyov, Alex S.,Ramirez, Jose,Halldorsdottir, Gudrun,Andresson, Thorkell,Gurney, Mark E.,Singh, Jasbir
scheme or table, p. 123 - 126 (2009/04/16)
A series of potent and selective EP3 receptor antagonists are described. Utilizing a pharmacophore model developed for the EP3 receptor, a series of 3,4-disubstituted indoles were shown to be high affinity ligands for this target. These compounds showed high selectivity over IP, FP and other EP receptors and are potent antagonists in functional assays.
