19116-90-6

Basic information

• Product Name: 2,5-DIMETHOXYBENZENESULFONAMIDE
• Synonyms: 2,5-DIMETHOXYBENZENESULFONAMIDE;2,5-DIMETHOXYBENZENESULPHONAMIDE;2,5-DIMETHOXYBENZENE-1-SULFONAMIDE;2,5-dimethoxy-benzenesulfonamid
• CAS NO: 19116-90-6
• Molecular Formula: C₈H₁₁NO₄S
• Molecular Weight: 217.24
• Mol File: 19116-90-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 150 °C
• Boiling Point: 416.2 °C at 760 mmHg
• Flash Point: 205.5 °C
• Appearance: /
• Density: 1.305 g/cm³
• Vapor Pressure: 3.9E-07mmHg at 25°C
• Refractive Index: 1.536
• CAS DataBase Reference: 2,5-DIMETHOXYBENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DIMETHOXYBENZENESULFONAMIDE(19116-90-6)
• EPA Substance Registry System: 2,5-DIMETHOXYBENZENESULFONAMIDE(19116-90-6)

Safety Data

• Hazard Codes: Xi
• Safety Statements: S24/25:Avoid contact with skin and eyes.
• RTECS: DB2030000
• HazardClass: IRRITANT
• Hazardous Substances Data: 19116-90-6(Hazardous Substances Data)

Usage

General Description

2,5-Dimethoxybenzenesulfonamide is a chemical compound with the molecular formula C8H11NO4S. It is a white or off-white crystalline powder and is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 2,5-DIMETHOXYBENZENESULFONAMIDE has a wide range of applications, including as an intermediate for the production of dyes, pigments, and other organic compounds. It is also used as a catalyst in various chemical reactions. Additionally, 2,5-Dimethoxybenzenesulfonamide is used as a reagent in the preparation of various pharmaceuticals and can be found as an ingredient in a variety of consumer products. Overall, this chemical has diverse uses in the chemical and pharmaceutical industries.

InChI:InChI=1/C8H11NO4S/c1-12-6-3-4-7(13-2)8(5-6)14(9,10)11/h3-5H,1-2H3,(H2,9,10,11)

Upstream product

• 1483-28-9 2,5-dimethoxybenzene-1-sulfonyl chloride 
• 150-78-7 1,4-dimethoxybezene 

Downstream Products

• 28011-66-7 N-((2,5-dimethoxyphenyl)sulfonyl)acetamide 
• 1057256-43-5 N-[2-(1H-Indol-4-yloxy)-acetyl]-2,5-dimethoxy-benzenesulfonamide 
• 128577-43-5 2-Cyclopentyl-N-{1-[4-(2,5-dimethoxy-benzenesulfonylaminocarbonyl)-2-methoxy-benzyl]-1H-indol-6-yl}-acetamide 

Relevant articles and documents

N-Acyl arylsulfonamides as novel, reversible inhibitors of human steroid sulfatase

Steroid sulfatase (STS) is an attractive target for a range of oestrogen- and androgen-dependent diseases. In search of novel chemotypes of STS inhibitors, we had previously identified nortropinyl-arylsulfonylureas 1; however, while these compounds were good inhibitors of purified STS (lowest Ki = 76 nM), they showed only weak inhibition of STS activity in cells (lowest IC50 around 2 μM). Extended structure-activity relationship studies involving modification of the phenylacetyl side chain and replacement of the nortropine element by simpler scaffolds led to the discovery of N-acyl arylsulfonamides, more specifically N-(Boc-piperidine-4-carbonyl)- benzenesulfonamides, as STS inhibitors, some of which exhibit improved cellular potency (best IC50 = 270 nM).

Herbicidal aryl triazolinones

Herbicidal aryl triazolinones include the compounds of the formula STR1 where X is preferably halogen such as fluorine, Y is preferably halogen such as chlorine, R1 is preferably methyl, R2 is preferably CHF2, R3 is preferably CH(CH3), and STR2 is --NH2 or the residue of a primary or secondary amine or of a sulfonamide.