1061337-55-0

Basic information

• Product Name: 14-O-{[(1S,2S,4S)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin
• Synonyms: 14-O-{[(1S,2S,4S)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin
• CAS NO: 1061337-55-0
• Molecular Weight: 507.735
• Mol File: 1061337-55-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 14-O-{[(1S,2S,4S)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin(CAS DataBase Reference)
• NIST Chemistry Reference: 14-O-{[(1S,2S,4S)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin(1061337-55-0)
• EPA Substance Registry System: 14-O-{[(1S,2S,4S)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin(1061337-55-0)

Safety Data

• Hazardous Substances Data: 1061337-55-0(Hazardous Substances Data)

Upstream product

• 31716-01-5 pleuromutilin tosylate 
• 4771-80-6 1,2,5,6-tetrahydrobenzoic acid 
• 1352833-87-4 tert-Butyl [(1S,3S,4S)-3-hydroxy-4-mercapto-cyclohexyl]-carbamate 
• 1350734-49-4 tert-butyl ((1S,3S,6R)-7-oxabicyclo[4.1.0]heptan-3-yl)carbamate 
• 1352834-09-3 cyclohex-3-ene-1-carboxylic acid (R)-(+)-1-phenylethanamine salt 
• 1350734-43-8 {(1S,2S,4S)-4-[(tert-butoxycarbonyl)-amino]-2-hydroxy-cyclohexyl}-benzene-carbothioate 
• 1061660-17-0 14-O-{[(1RS,2RS,4RS)-4-tert-butoxycarbonylamino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin 

Downstream Products

• 1352833-93-2 14-O-{[(1S,2S,4S)-4-amino-2-hydroxy-cyclohexyl-sulfanyl]-acetyl}-mutilin acetate 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF PLEUROMUTILINS

Process for the preparation of a Compound of formula I in the form of a single stereoisomer in crystalline form, comprising deprotecting the amine group in a Compound of formula IIa or in a mixture of a compound of formula IIa With a compound of formula IIb and isolating a Compound of formula I from the reaction mixture; Compounds and salts of Compounds of formula I in crystalline form; pharmaceutical compositions comprising such salts; processes for the preparation of intermediates and intermediates in a process for the preparation of a Compound of formula I.

Pleuromutilin derivatives for the treatment of diseases mediated by microbes

A compound of formula (I) wherein n is 0 to 4; R is ethyl or vinyl; R1 is hydrogen or (C1-6)alkyl, R2 is hydrogen or - cycloalkyl including (C3-6)cycloalkyl, or - unsubstituted (C1-6)alkyl, or - (C1-6)alkyl substituted by one or more of - hydroxy; preferably one or two, - halogen, - (C3-6)cycloalkyl, or R1 is hydroxy and R2 is formyl.