1062368-62-0 Usage
Description
LDN-193189 HCl, also known as 4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline Hydrochoride, is a selective inhibitor of the bone morphogenetic protein (BMP) pathway. It is a synthetic compound that has been developed to target and inhibit the activity of BMP type I receptors, playing a crucial role in various biological processes and diseases.
Uses
Used in Medical Research:
LDN-193189 HCl is used as a research tool for studying the pathogenesis of fibrodysplasia ossificans progressive, a congenital hyperossification disorder. By inhibiting BMP type I receptor activity, it helps researchers understand the underlying mechanisms and potential therapeutic approaches for this condition.
Used in Oncology:
LDN-193189 HCl is used as a therapeutic agent for examining the role of osteogenesis in prostate tumor metastases in bone. Its ability to inhibit the BMP pathway makes it a promising candidate for exploring the potential of targeting this pathway in the treatment of bone metastases from prostate cancer.
Used in Drug Development:
LDN-193189 HCl is used as a selective inhibitor of the bone morphogenetic protein (BMP) pathway, which is useful in the treatment of various diseases. Its specificity for the BMP pathway allows for targeted intervention in conditions where this pathway is dysregulated, offering a potential therapeutic strategy for disease management and treatment.
Biological Activity
ldn193189 is a selective transcriptional activity morphogenetic protein (bmp) type i receptors inhibitor. it inhibits activin receptor-like kinase-2 (alk2) and alk3 with ic50 values of 5 nm and 30 nm, respectively [1].ldn193189 has been showed to inhibit bmp induced phosphorylation of smad signaling (smad1/5/8) and non-smad signaling including p38 and akt in c2c12 cells [2].pharmacological inhibition of bmp by ldn193189 has shown to prevent down-regulation of e-cadherin in response to bmp2 both in bronchial epithelial (beas2b) cells and in c57bl/6 mice. ldn193189 also inhibits the bmp-induced reduction of epithelial permeability at cellular level [3].
Check Digit Verification of cas no
The CAS Registry Mumber 1062368-62-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,6,2,3,6 and 8 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1062368-62:
(9*1)+(8*0)+(7*6)+(6*2)+(5*3)+(4*6)+(3*8)+(2*6)+(1*2)=140
140 % 10 = 0
So 1062368-62-0 is a valid CAS Registry Number.
1062368-62-0Relevant articles and documents
INHIBITORS OF THE BMP SIGNALING PATHWAY
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, (2009/10/22)
The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation.
