1062368-25-5

Basic information

• Product Name: C₂₁H₂₅N₅O₂
• Synonyms: C₂₁H₂₅N₅O₂
• CAS NO: 1062368-25-5
• Molecular Weight: 379.462
• Mol File: 1062368-25-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₅N₅O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₅N₅O₂(1062368-25-5)
• EPA Substance Registry System: C₂₁H₂₅N₅O₂(1062368-25-5)

Safety Data

• Hazardous Substances Data: 1062368-25-5(Hazardous Substances Data)

Upstream product

• 705263-10-1 6-bromo-pyrazolo[1,5-α]pyrimidine 
• 470478-90-1 tert-butyl 4-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]piperazine-1-carboxylate 

Downstream Products

• 1062368-26-6 tert-butyl 4-(4-(3-bromopyrazolo[1,5-a]pyrimidin-6-yl)phenyl)piperazine-1-carboxylate 
• 1432597-26-6 5-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline 
• 1062368-27-7 C₃₀H₃₀N₆O₂ 
• 1062368-62-0 4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline hydrochloride 

Relevant articles and documents

A synthetic bone morphogenetic protein receptor inhibitors

The invention discloses a method for synthesizing a bone morphogenetic protein receptor inhibitor, and solves the problem of long inhibitor synthesis route in the prior art. The method comprises the following steps: 1, obtaining an intermediate represented by formula (III) shown in the specification, wherein R1 in the formula (III) can be a first formula or a second formula also shown in the specification; 2, adding 5-bromoquinoline to the intermediate represented by formula (III), adding potassium acetate and palladium acetate, adding N,N-dimethyl acetamide, reacting, and cooling to room temperature; and 3, adding water to precipitate a solid when the R1 is the first formula, drying, and separating to obtain a product 1; and extracting the above obtained reaction solution by ethyl acetate when the R1 is the second formula, drying the obtained organic phase to remove a solvent, separating to obtain the product 1, dissolving the product 1 in methanol, adding concentrated hydrochloric acid, reacting to precipitate a solid, carrying out pumping filtration, washing, and drying to obtain a product 2. The method has the advantages of short preparation steps, low price of adopted raw materials, and high yield of target products.

INHIBITORS OF THE BMP SIGNALING PATHWAY

The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation.